JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB196880

Anti-MERTK antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal MERTK antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MERTK.

View Alternative Names

MER, MERTK, Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK

1 Images
Western blot - Anti-MERTK antibody (AB196880)
  • WB

Supplier Data

Western blot - Anti-MERTK antibody (AB196880)

All lanes:

Western blot - Anti-MERTK antibody (ab196880) at 1/500 dilution

Lane 1:

3T3 cell extracts with blocking peptide

Lane 2:

3T3 cell extracts

Predicted band size: 110 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MERTK. The exact immunogen used to generate this antibody is proprietary information.

Q12866

style
left-column

Alternative Products

Primary Antibodies

AB270448

Anti-MERTK antibody [EPR23248-259]

RabMAb|Recombinant

Western blot - Anti-MERTK antibody [EPR23248-259] (AB270448)

  • 0
  • 0
Primary Antibodies

AB14921

Anti-MERTK (phospho Y749 + Y753 + Y754) antibody

  • 0
  • 0
Primary Antibodies

AB192649

Anti-MERTK (phospho Y749) + TYRO3 (phospho Y681) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MERTK (phospho Y749) + TYRO3 (phospho Y681) antibody (AB192649)

  • 0
  • 0
Primary Antibodies

AB197643

HRP Anti-MERTK antibody [Y323]

RabMAb|Recombinant

Western blot - HRP Anti-MERTK antibody [Y323] (AB197643)

  • 0
  • 0
Primary Antibodies

AB184086

Anti-MERTK antibody [EPR17534-139]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MERTK antibody [EPR17534-139] (AB184086)

  • 0
  • 0
Primary Antibodies

AB52968

Anti-MERTK antibody [Y323]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Frozen sections) - Anti-MERTK antibody [Y323] (AB52968)

  • 5
  • 4
Primary Antibodies

AB95925

Anti-MERTK antibody

Immunocytochemistry/ Immunofluorescence - Anti-MERTK antibody (AB95925)

  • 0
  • 0
Primary Antibodies

AB176887

Anti-MERTK antibody [Y323] - Low endotoxin, Azide free

RabMAb|KO Validated|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MERTK antibody [Y323] - Low endotoxin, Azide free (AB176887)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB109231

Anti-TYRO3 antibody [EPR4308]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TYRO3 antibody [EPR4308] (AB109231)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB178846

Anti-Iba1 antibody [EPR16588] - Microglia marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Iba1 antibody [EPR16588] - Microglia marker (AB178846)

  • 5
  • 49
Primary Antibodies

AB264098

Anti-GAS 6 antibody [EPR23931-27]

20ul selling size|RabMAb|Recombinant|KO Validated|Trial Size

Flow Cytometry (Intracellular) - Anti-GAS 6 antibody [EPR23931-27] (AB264098)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MERTK protein also known as c-Mer tyrosine kinase plays a mechanical role as a receptor tyrosine kinase with a mass of approximately 110 kDa. It is expressed in multiple tissues including the retina immune cells and some epithelial cells. MERTK functions by binding with its ligands facilitating downstream signaling that affects cellular functions. The receptor is part of the TAM family alongside proteins like AXL and TYRO3.
Biological function summary

The receptor MERTK orchestrates processes critical for maintaining cellular homeostasis such as efferocytosis and immune response regulation. It does not operate alone but often interacts with other cellular components to form functional complexes. This protein contributes significantly to phagocytosis a cellular process for clearing apoptotic cells ensuring a controlled immune environment.

Pathways

Several signal transduction pathways involve c-Mer tyrosine kinase in maintaining cellular communication. Notably it participates in the RAS/MAPK and PI3K/AKT pathways which are essential for cell survival and proliferation. These pathways involve interactions with proteins such as GAB1 and SOS highlighting the receptor's integration in cell signaling networks.

Aberrant activity of MERTK has associations with cancer and autoimmune disorders. In cancers such as leukemia overexpression of the MERTK protein promotes cell survival and proliferation. Its interaction with other proteins like GRB2 can further exacerbate oncogenic pathways. In autoimmune diseases dysregulated MERTK expression can lead to improper clearance of apoptotic cells contributing to systemic inflammation.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed : 32640697). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
See full target information MERTK
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 53: PubMed40548942

2025

The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1.

Applications

Unspecified application

Species

Unspecified reactive species

Fabian Gather,Tudor Rauleac,Ipek Akol,Ganeshkumar Arumugam,Camila L Fullio,Teresa Müller,Dimitrios Kleidonas,Ruth Geiss-Friedlander,Andre Fischer,Andreas Vlachos,Rolf Backofen,Tanja Vogel
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com