AB14921

Anti-MERTK (phospho Y749 + Y753 + Y754) antibody

Name: Anti-MERTK (phospho Y749 + Y753 + Y754) antibody (ab14921) | Abcam
Brand: Abcam Limited
SKU: AB14921
Price: 585 USD
Availability: InStock

Be the first to review this product! Submit a review

(17 Publications)

Rabbit Polyclonal antibody. Suitable for WB and reacts with Human samples. Cited in 17 publications. Immunogen corresponding to Synthetic Peptide within Human MERTK phospho Y753 + Y754 aa 700-800.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human MERTK phospho Y753 + Y754 aa 700-800. The exact immunogen used to generate this antibody is proprietary information.

Q12866

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Affinity purified.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 30% Glycerol (glycerin, glycerine), 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MERTK protein also known as c-Mer tyrosine kinase plays a mechanical role as a receptor tyrosine kinase with a mass of approximately 110 kDa. It is expressed in multiple tissues including the retina immune cells and some epithelial cells. MERTK functions by binding with its ligands facilitating downstream signaling that affects cellular functions. The receptor is part of the TAM family alongside proteins like AXL and TYRO3.

Biological function summary

The receptor MERTK orchestrates processes critical for maintaining cellular homeostasis such as efferocytosis and immune response regulation. It does not operate alone but often interacts with other cellular components to form functional complexes. This protein contributes significantly to phagocytosis a cellular process for clearing apoptotic cells ensuring a controlled immune environment.

Pathways

Several signal transduction pathways involve c-Mer tyrosine kinase in maintaining cellular communication. Notably it participates in the RAS/MAPK and PI3K/AKT pathways which are essential for cell survival and proliferation. These pathways involve interactions with proteins such as GAB1 and SOS highlighting the receptor's integration in cell signaling networks.

Aberrant activity of MERTK has associations with cancer and autoimmune disorders. In cancers such as leukemia overexpression of the MERTK protein promotes cell survival and proliferation. Its interaction with other proteins like GRB2 can further exacerbate oncogenic pathways. In autoimmune diseases dysregulated MERTK expression can lead to improper clearance of apoptotic cells contributing to systemic inflammation.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

style

left-column

Publications (17)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 29:110 PubMed40242601

2025

Repurposing of the Syk inhibitor fostamatinib using a machine learning algorithm.

Applications

Unspecified application

Species

Unspecified reactive species

Yoonjung Choi,Heejin Lee,Bo Ram Beck,Bora Lee,Ji Hyun Lee,Seoree Kim,Sang Hoon Chun,Hye Sung Won,Yoon Ho Ko

iScience 27:109048 PubMed38464592

2024

Specific knockout of macrophage SHP2 promotes macrophage M2 polarization and alleviates renal ischemia-reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Meilian Du,Shanbao Zhang,Xiaoyu Wang,Chen Liu,Linrong Pan,Xiao Chen,Yinghui Qi

Medical oncology (Northwood, London, England) 40:284 PubMed37644281

2023

Targeting MerTK decreases efferocytosis and increases anti-tumor immune infiltrate in prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Kayla V Myers Chen,Amber E de Groot,Sabrina A Mendez,Mikaela M Mallin,Sarah R Amend,Kenneth J Pienta

Cancers 14: PubMed36230744

2022

A Novel Selective Axl/Mer/CSF1R Kinase Inhibitor as a Cancer Immunotherapeutic Agent Targeting Both Immune and Tumor Cells in the Tumor Microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Yeejin Jeon,Hwankyu Kang,Yeongin Yang,Dongsik Park,Baejung Choi,Jeongjun Kim,Jaeseung Kim,Kiyean Nam

Frontiers in pharmacology 13:981996 PubMed36225585

2022

Macrophage malfunction in Triptolide-induced indirect hepatotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Qin,Muhammad Hasnat,Yang Zhou,Ziqiao Yuan,Wenzhou Zhang

Redox biology 54:102366 PubMed35728303

2022

N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth.

Applications

Unspecified application

Species

Unspecified reactive species

Yongzhang Liu,Linhua Lan,Yujie Li,Jing Lu,Lipeng He,Yao Deng,Mingming Fei,Jun-Wan Lu,Fugen Shangguan,Ju-Ping Lu,Jiaxin Wang,Liang Wu,Kate Huang,Bin Lu

Journal of immunology (Baltimore, Md. : 1950) 206:677-685 PubMed33419766

2021

Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Lu,Li Chen,Anthony G Mansour,Melissa J Yu,Noah Brooks,Kun-Yu Teng,Zhenlong Li,Jianying Zhang,Tasha Barr,Jianhua Yu,Michael A Caligiuri

Cell death and differentiation 28:1284-1300 PubMed33139930

2020

KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wenwen Du,Jianjie Zhu,Yuanyuan Zeng,Ting Liu,Yang Zhang,Tingting Cai,Yulong Fu,Weijie Zhang,Ruochen Zhang,Zeyi Liu,Jian-An Huang

Journal of enzyme inhibition and medicinal chemistry 35:1822-1833 PubMed32972253

2020

Structure-activity relationship of 7-aryl-2-anilino-pyrrolopyrimidines as Mer and Axl tyrosine kinase inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Shin Hyuck Chung,Jiwon Park,Jung Wuk Lee,Jiho Song,Danbee Jung,Kyung Hoon Min

The Journal of clinical investigation 128:5034-5055 PubMed30188867

2018

Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Seo Hee Nam,Doyeun Kim,Doohyung Lee,Hye-Mi Lee,Dae-Geun Song,Jae Woo Jung,Ji Eon Kim,Hye-Jin Kim,Nam Hoon Kwon,Eun-Kyeong Jo,Sunghoon Kim,Jung Weon Lee

View all publications

style

left-column

style

left-column

style

right-column

Alternative Products

Primary Antibodies

AB52591

Anti-MERTK antibody [A311F9G3]

Flow Cytometry - Anti-MERTK antibody [A311F9G3] (AB52591)

Primary Antibodies

AB192649

Anti-MERTK (phospho Y749) + TYRO3 (phospho Y681) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MERTK (phospho Y749) + TYRO3 (phospho Y681) antibody (AB192649)

Primary Antibodies

AB196880

Anti-MERTK antibody

Western blot - Anti-MERTK antibody (AB196880)

Primary Antibodies

AB216564

Anti-MERTK antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MERTK antibody (AB216564)

Primary Antibodies

AB70693

Anti-MERTK antibody

Western blot - Anti-MERTK antibody (AB70693)

Primary Antibodies

AB197643

HRP Anti-MERTK antibody [Y323]

RabMAb|Recombinant

Western blot - HRP Anti-MERTK antibody [Y323] (AB197643)

Primary Antibodies

AB184086

Anti-MERTK antibody [EPR17534-139]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MERTK antibody [EPR17534-139] (AB184086)

Primary Antibodies

AB52968

Anti-MERTK antibody [Y323]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Frozen sections) - Anti-MERTK antibody [Y323] (AB52968)

Primary Antibodies

AB238516

Anti-MERTK antibody [NO.H1B0]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MERTK antibody [NO.H1B0] (AB238516)

Primary Antibodies

AB95925

Anti-MERTK antibody

Immunocytochemistry/ Immunofluorescence - Anti-MERTK antibody (AB95925)

Primary Antibodies

AB176887

Anti-MERTK antibody [Y323] - Low endotoxin, Azide free

RabMAb|KO Validated|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MERTK antibody [Y323] - Low endotoxin, Azide free (AB176887)

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

Primary Antibodies

AB955

Anti-CD68 antibody [KP1]

Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [KP1] (AB955)

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com