AB188750

Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal

Name: Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (ab188750) | Abcam
Brand: Abcam Limited
SKU: AB188750
Price: 605 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal Metabotropic Glutamate Receptor 3/MGLUR3 antibody. N-terminal. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human GRM3.

View Alternative Names

GPRC1C, MGLUR3, GRM3, Metabotropic glutamate receptor 3, mGluR3

7 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunohistochemical analysis of Human Kidney tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.

Immunocytochemistry/ Immunofluorescence - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunocytochemistry of HEK293 Human embryonic kidney cells transfected with Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10ug/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunohistochemical analysis of Human brain, Glioblastoma tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunohistochemical analysis of Human Testies tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunohistochemical analysis of Human brain, coroid plexus tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 38 μg/ml.

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunocytochemical analysis of HEK293 tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunohistochemical analysis of Human skin melanoma tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human GRM3. The exact immunogen used to generate this antibody is proprietary information.

Q14832

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5-15 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

See full target information GRM3

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 12:723 PubMed34290229

2021

Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Julian P Maier,Vidhya M Ravi,Jan Kueckelhaus,Simon P Behringer,Niklas Garrelfs,Paulina Will,Na Sun,Jasmin von Ehr,Jonathan M Goeldner,Dietmar Pfeifer,Marie Follo,Luciana Hannibal,Axel Karl Walch,Ulrich G Hofmann,Jürgen Beck,Dieter Henrik Heiland,Oliver Schnell,Kevin Joseph

FASEB journal : official publication of the Federa 33:13734-13746 PubMed31585509

2019

Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Lisa Klotz,Olaf Wendler,Renato Frischknecht,Ryuichi Shigemoto,Holger Schulze,Ralf Enz

Journal of psychopharmacology (Oxford, England) 31:1519-1526 PubMed28655286

2017

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding.

Applications

Species

Unspecified reactive species

Aintzane García-Bea,Isabel Bermudez,Paul J Harrison,Tracy A Lane

Journal of neuroendocrinology 29: PubMed28071834

2017

Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Hypothalamic Neurones Provides Developmental Insights into Genetic Loci for Body Weight Regulation.

Applications

Unspecified application

Species

Unspecified reactive species

L Yao,Y Liu,Z Qiu,S Kumar,J E Curran,J Blangero,Y Chen,D M Lehman

Schizophrenia research 177:18-27 PubMed27130562

2016

Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study.

Applications

Species

Mouse

Aintzane García-Bea,Mary A Walker,Thomas M Hyde,Joel E Kleinman,Paul J Harrison,Tracy A Lane

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunocytochemistry/ Immunofluorescence - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunocytochemistry/ Immunofluorescence - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (AB188750)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (5)

Product promise