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AB235775

Anti-METRNL antibody

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(5 Publications)

Rabbit Polyclonal METRNL antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human METRNL.

View Alternative Names

Meteorin-like protein, Subfatin, METRNL

1 Images
Western blot - Anti-METRNL antibody (AB235775)
  • WB

Supplier Data

Western blot - Anti-METRNL antibody (AB235775)

All lanes:

Western blot - Anti-METRNL antibody (ab235775) at 1/500 dilution

Lane 1:

Mouse small intestine tissue lysate

Lane 2:

Mouse kidney tissue lysate

Lane 3:

Rat gonad tissue lysate

Lane 4:

Mouse brain tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 34 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human METRNL.

Q641Q3

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

METRNL also known as Meteorin-like protein weighs approximately 33 kDa and plays an essential role in adipose tissue and muscle function. Expression of METRNL occurs in skeletal muscle and adipose tissue showcasing its importance in these tissues. METRNL being a secreted protein facilitates communication between cells in these tissues which means it participates in various physiological processes related to these areas.
Biological function summary

Meteorin-like protein influences energy expenditure and thermogenesis. It enhances the browning of white adipose tissue leading to increased metabolic activity. METRNL acts as an upstream regulator for several metabolic pathways and interacts with cells involved in immune response signifying a potential role in regulating inflammation. While METRNL itself does not form a large protein complex it interacts with a network of signaling molecules that mediate its effects on energy balance.

Pathways

The action of Meteorin-like protein integrates into pathways influencing the immune system and metabolism. METRNL has a functional link to the signal transducer and activator of transcription 3 (STAT3) pathway where it modulates cellular processes related to metabolism and inflammation. Additionally METRNL impacts the AMP-activated protein kinase (AMPK) pathway critical for energy homeostasis through its ability to enhance the browning of adipose tissue. These pathways underline METRNL's role in metabolic regulation and immune responses.

METRNL's functional attributes link it to metabolic diseases like obesity and insulin resistance. Its role in promoting energy expenditure and reducing pro-inflammatory signals showcases its potential relevance in these conditions. Additionally METRNL may influence muscle-related disorders due to its impact on muscle function. Through these pathways METRNL interacts with proteins like interleukin-6 (IL-6) known for its involvement in metabolic syndrome and inflammatory responses providing new insights into therapeutic strategies for managing these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
See full target information METRNL
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:405 PubMed40393967

2025

Cellular crosstalk mediated by Meteorin-like regulating hepatic stellate cell activation during hepatic fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxia Zhou,Guifang Wang,Lingling Liu,Lingyu Song,Laying Hu,Lu Liu,Lifen Xu,Tuanlao Wang,Lirong Liu,Yuanyuan Wang,Tian Zhang,Bing Guo

CNS neuroscience & therapeutics 31:e70286 PubMed39981761

2025

Metrnl/C-KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

You Zhou,Jiani Li,Ye Yuan,Hao Zhang,Xu Luo,Feng Wang,Yihao Tao,Jianhe Yue,Luyi Huang,Lei Wu,Yunxing Cao,Qian Yu,Qiuguang He

International archives of allergy and immunology 186:496-508 PubMed39581185

2024

Metrnl/IL-41 Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Inflammatory Responses through the AMPK/SIRT1 Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Guannan Wang,Danqin Liu,Kejing Zhang,Yan Wang,Zhiwei Xu

Genes & diseases 11:101100 PubMed39281832

2024

Elevated meteorin-like protein from high-intensity interval training improves heart function via AMPK/HDAC4 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yongshun Wang,Jie Yuan,Huadong Liu,Jie Chen,Jieru Zou,Xiaoyi Zeng,Lei Du,Xin Sun,Zhengyuan Xia,Qingshan Geng,Yin Cai,Jingjin Liu

Aging 11:9778-9793 PubMed31727867

2019

Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2.

Applications

Unspecified application

Species

Unspecified reactive species

Yanhua Du,Jun Lin,Rulin Zhang,Wanli Yang,Heng Quan,Lijuan Zang,Yaqin Han,Bing Li,Hong Sun,Jun Wu
View all publications
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