Anti-METRNL antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

METRNL also known as Meteorin-like protein weighs approximately 33 kDa and plays an essential role in adipose tissue and muscle function. Expression of METRNL occurs in skeletal muscle and adipose tissue showcasing its importance in these tissues. METRNL being a secreted protein facilitates communication between cells in these tissues which means it participates in various physiological processes related to these areas.

Biological function summary

Meteorin-like protein influences energy expenditure and thermogenesis. It enhances the browning of white adipose tissue leading to increased metabolic activity. METRNL acts as an upstream regulator for several metabolic pathways and interacts with cells involved in immune response signifying a potential role in regulating inflammation. While METRNL itself does not form a large protein complex it interacts with a network of signaling molecules that mediate its effects on energy balance.

Pathways

The action of Meteorin-like protein integrates into pathways influencing the immune system and metabolism. METRNL has a functional link to the signal transducer and activator of transcription 3 (STAT3) pathway where it modulates cellular processes related to metabolism and inflammation. Additionally METRNL impacts the AMP-activated protein kinase (AMPK) pathway critical for energy homeostasis through its ability to enhance the browning of adipose tissue. These pathways underline METRNL's role in metabolic regulation and immune responses.

Associated diseases and disorders

METRNL's functional attributes link it to metabolic diseases like obesity and insulin resistance. Its role in promoting energy expenditure and reducing pro-inflammatory signals showcases its potential relevance in these conditions. Additionally METRNL may influence muscle-related disorders due to its impact on muscle function. Through these pathways METRNL interacts with proteins like interleukin-6 (IL-6) known for its involvement in metabolic syndrome and inflammatory responses providing new insights into therapeutic strategies for managing these disorders.