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AB72660

Anti-METTL11A antibody

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(4 Publications)

Mouse Polyclonal METTL11A antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NTMT1.

View Alternative Names

C9orf32, METTL11A, NRMT, NRMT1, AD-003, NTMT1, N-terminal Xaa-Pro-Lys N-methyltransferase 1, Alpha N-terminal protein methyltransferase 1A, Methyltransferase-like protein 11A, N-terminal RCC1 methyltransferase, X-Pro-Lys N-terminal protein methyltransferase 1A, NTM1A

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NTMT1.

Q9BV86

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB317553

Anti-Integrin alpha 1 antibody [EPR27291-17]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

METTL11A also known as PCMT1 or methyltransferase-like protein 11A functions mechanically as a protein methyltransferase specifically responsible for the methylation of the N-terminal alpha-amino group on proteins. This methylation process affects the function and stability of target proteins. METTL11A exhibits a molecular mass of approximately 32 kDa. It is widely expressed in human tissues particularly in the liver and brain indicating its important role in different physiological contexts.
Biological function summary

The enzyme influences protein interactions by modifying proteins at the molecular level impacting their stability and function. METTL11A contributes to various processes including protein repair and turnover mechanisms. It may operate independently or within larger protein complexes though further research is necessary to identify specific complex partners. This enzymatic activity is fundamental for maintaining protein homeostasis and ensuring proper cellular function.

Pathways

METTL11A engages in the protein methylation pathway which is vital for regulating protein function and interactions. This pathway often involves other key proteins such as PCMT1 that work together to methylate proteins and modify their activities. Additionally METTL11A plays a significant role in the protein repair pathway where it repairs damaged proteins assisting in the prevention of cellular stress and damage.

METTL11A could have implications in neurological disorders like Alzheimer's disease. Alzheimer's has been linked to disrupted protein metabolism where the absence or malfunction of METTL11A activity affects protein stability and accumulation. Furthermore METTL11A's interactions with proteins such as PCMT1 might complicate the protein methylation processes potentially contributing to liver disease by disrupting normal cellular protein functions in the liver emphasizing the importance of METTL11A in disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed : 24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
See full target information NTMT1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 8:14 PubMed35013138

2022

Knockdown of NRMT enhances sensitivity of retinoblastoma cells to cisplatin through upregulation of the CENPA/Myc/Bcl2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongrui Li,Lan Zhang,Dongrui Liu,Zhanghui Yang,Di Xuan,Yi Zhang

Experimental & molecular medicine 53:1092-1108 PubMed34188179

2021

Disruption of nucleocytoplasmic trafficking as a cellular senescence driver.

Applications

Unspecified application

Species

Unspecified reactive species

Ji-Hwan Park,Sung Jin Ryu,Byung Ju Kim,Hyun-Ji Cho,Chi Hyun Park,Hyo Jei Claudia Choi,Eun-Jin Jang,Eun Jae Yang,Jeong-A Hwang,Seung-Hwa Woo,Jun Hyung Lee,Ji Hwan Park,Kyung-Mi Choi,Young-Yon Kwon,Cheol-Koo Lee,Joon Tae Park,Sung Chun Cho,Yun-Il Lee,Sung Bae Lee,Jeong A Han,Kyung A Cho,Min-Sik Kim,Daehee Hwang,Young-Sam Lee,Sang Chul Park

Biochemical and biophysical research communications 546:54-58 PubMed33561748

2021

Modulation of N-terminal methyltransferase 1 by an N-methyladenosine-based epitranscriptomic mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

David Bade,Qian Cai,Lin Li,Kailin Yu,Xiaoxia Dai,Weili Miao,Yinsheng Wang

Transplantation 96:791-9 PubMed23958924

2013

Activation of the lectin pathway of complement in pig-to-human xenotransplantation models.

Applications

Unspecified application

Species

Unspecified reactive species

Anjan K Bongoni,David Kiermeir,Hansjörg Jenni,Annegret Wünsch,Andrea Bähr,David Ayares,Jörg D Seebach,Eckhard Wolf,Nikolai Klymiuk,Mihai A Constantinescu,Esther Vögelin,Robert Rieben
View all publications
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Product promise

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