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AB279378

Anti-METTL21A antibody [OTI2G7]

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(1 Publication)

Mouse Monoclonal METTL21A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human METTL21A.

View Alternative Names

FAM119A, HCA557B, METTL21A, Protein N-lysine methyltransferase METTL21A, HSPA lysine methyltransferase, HSPA-KMT, Hepatocellular carcinoma-associated antigen 557b, Methyltransferase-like protein 21A

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-METTL21A antibody [OTI2G7] (AB279378)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-METTL21A antibody [OTI2G7] (AB279378)

Paraffin embedded Human pancreas tissue stained for FAM119A using ab279378 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10minutes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-METTL21A antibody [OTI2G7] (AB279378)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-METTL21A antibody [OTI2G7] (AB279378)

Paraffin embedded carcinoma of human lung tissue stained for FAM119A using ab279378 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10minutes.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI2G7

Isotype

IgG2b

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human METTL21A.

Q8WXB1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

METTL21A also known as FAM119A is a methyltransferase enzyme involved in protein methylation. It belongs to the METTL (methyltransferase-like) family and has a molecular weight of approximately 28 kDa. METTL21A is ubiquitously expressed in various tissues with relatively higher levels in the kidney and liver. It acts through catalyzing the transfer of methyl groups to target proteins often modifying lysine residues which can influence protein function and stability.
Biological function summary

METTL21A functions in protein post-translational modification and plays a role in regulating protein interactions and signaling pathways. Although not strictly part of a specific complex METTL21A interacts with substrates and partner proteins affecting cellular function. The enzyme's activity can influence cellular processes such as signaling growth and apoptosis which are essential for normal cellular homeostasis.

Pathways

METTL21A participates in the modulation of signaling pathways like the mTOR pathway. This pathway is important for cell growth and metabolism wherein METTL21A may impact its regulation through methylation of pathway-related proteins. Relationships with other methyltransferases or signaling proteins such as those in the S6K family demonstrate its significance in controlling biological responses to nutrients and growth factors.

METTL21A associates with metabolic diseases and certain cancers. Its altered expression or function can contribute to abnormal protein methylation which is evident in some forms of cancer possibly affecting tumor growth and progression. Furthermore METTL21A's influence on metabolic pathways implicates it in disorders related to metabolic dysregulation potentially intersecting with proteins like mTOR and AMPK that are key players in cellular energy homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.
See full target information METTL21A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2301753 PubMed37382161

2023

TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.

Applications

Unspecified application

Species

Unspecified reactive species

Mengqiu Wu,Qianqian Jin,Xinyue Xu,Jiaojiao Fan,Weiyi Chen,Mengqiu Miao,Ran Gu,Shengnan Zhang,Yan Guo,Songming Huang,Yue Zhang,Aihua Zhang,Zhanjun Jia
View all publications
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Product promise

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