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AB122669

Anti-METTL22 antibody

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(1 Publication)

Rabbit Polyclonal METTL22 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human METTL22 aa 200-350.

View Alternative Names

C16orf68, LP8272, METTL22, Methyltransferase-like protein 22

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-METTL22 antibody (AB122669)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-METTL22 antibody (AB122669)

ab122669, at 1/50 dilution, staining METTL22 in paraffin-embedded Human rectum tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human METTL22 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

Q9BUU2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

METTL22 also known as Methyltransferase Like 22 is a protein with a mass of approximately 45 kDa. It functions as an S-adenosylmethionine-dependent methyltransferase transferring methyl groups to specific substrates though its exact substrates remain under investigation. METTL22 is expressed in various tissues including the liver lungs and the central nervous system. Its expression may vary depending on the specific cell type or physiological context.
Biological function summary

METTL22 plays a role in cellular processes like gene expression regulation and RNA processing. It can act independently or as part of protein complexes engaging in the modification of RNA or proteins through methylation. This activity impacts the stability and translation of mRNA highlighting its significance in post-transcriptional control. METTL22's methylation activity influences cellular functions by affecting how RNA molecules behave and interact within cells.

Pathways

METTL22 participates mostly in epigenetic and RNA processing pathways. It associates with the RNA methylation pathway which modulates mRNA stability and translation efficiency sharing connections with proteins such as METTL3 and METTL14. Additionally METTL22 has a role in chromatin remodeling pathways influencing gene expression regulation where it cooperates with other chromatin-modifying proteins.

METTL22 has implications in cancer and neurological disorders. Abnormal METTL22 expression or mutations may disrupt methylation patterns contributing to oncogenesis through dysregulated gene expression. In cancer METTL22 interactions with proteins like METTL3 may exacerbate tumor progression by affecting RNA methylation processes. In neurological disorders aberrant METTL22 function can affect neuronal gene regulation potentially linking it to neurodevelopmental conditions though the precise mechanisms require further research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protein N-lysine methyltransferase. Trimethylates KIN at Lys-135 (in vitro).
See full target information METTL22
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Virologica Sinica 39:501-512 PubMed38789039

2024

Calmodulin-like 5 promotes PEDV replication by regulating late-endosome synthesis and innate immune response.

Applications

Unspecified application

Species

Unspecified reactive species

Wen-Jun Tian,Xiu-Zhong Zhang,Jing Wang,Jian-Feng Liu,Fu-Huang Li,Xiao-Jia Wang
View all publications
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