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AB101510

Anti-METTL2B antibody

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(1 Publication)

Rabbit Polyclonal METTL2B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human METTL2B aa 1-200.

View Alternative Names

tRNA N(3)-cytidine methyltransferase METTL2B, Methyltransferase-like protein 2B, METTL2B

1 Images
Western blot - Anti-METTL2B antibody (AB101510)
  • WB

Unknown

Western blot - Anti-METTL2B antibody (AB101510)

10% SDS PAGE

All lanes:

Western blot - Anti-METTL2B antibody (ab101510) at 1/1000 dilution

All lanes:

IMR32 whole cell lysate at 30 µg

Predicted band size: 43 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human METTL2B aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q6P1Q9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

METTL2B also known as Methyltransferase-like protein 2B serves as a methyltransferase enzyme. It has a mass around 55 kDa. This protein mainly functions in the methylation of RNA molecules. METTL2B is expressed in various tissues with higher levels in organs like liver and brain. It specifically methylates some RNA nucleotides which can influence RNA stability and processing.
Biological function summary

METTL2B exerts influence by acting on RNA substrates modifying their properties and affecting gene expression regulation. It becomes part of methylation complexes though the exact components of these complexes still require precise characterization. Through its enzymatic activity METTL2B plays a role in genomic stability and through these actions can impact cell development and differentiation.

Pathways

METTL2B influences several key biological cascades. It participates in RNA processing pathways and has connections to cellular signaling pathways important for maintaining normal cell function. In RNA processing METTL2B's activity is linked with other RNA methylation proteins such as METTL3 and METTL14 forming pathways that ensure proper RNA maturation and stability.

METTL2B has associations with certain cancers and neurological disorders. Abnormal expression levels of METTL2B can contribute to the development of cancers like hepatocellular carcinoma due to altered methylation patterns. Furthermore its dysregulation is related to neurological disorders such as schizophrenia where it might interact with proteins like FMRP impacting synaptic function and neuronal communication.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).
See full target information METTL2B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Current issues in molecular biology 47: PubMed41020815

2025

The Axis Modulates the Immunosuppressive Tumor Microenvironment and Predicts Immunotherapy Response in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenxing Wang,Xia Li,Shiyi Zhang,Jiamin Sun,Qinchen Lu,Yuting Tao,Shuang Liang,Xiuwan Lan,Jianhong Zhong,Qiuyan Wang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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