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AB79207

Anti-METTL7A antibody

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(3 Publications)

Rabbit Polyclonal METTL7A antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TMT1A.

View Alternative Names

METTL7A, PRO0066, UNQ1902/PRO4348, TMT1A, Thiol S-methyltransferase TMT1A, Methyltransferase-like protein 7A, N6-adenosine-methyltransferase TMT1A, Protein AAM-B, Thiol methyltransferase 1A

1 Images
Western blot - Anti-METTL7A antibody (AB79207)
  • WB

Unknown

Western blot - Anti-METTL7A antibody (AB79207)

All lanes:

Western blot - Anti-METTL7A antibody (ab79207) at 2 µg/mL

All lanes:

MCF7 cell lysate at 15 µg

Predicted band size: 28 kDa

Observed band size: 28 kDa,30 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TMT1A. The exact immunogen used to generate this antibody is proprietary information.

Q9H8H3

Specificity

This antibody is predicted to not cross react with METTL7B.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2-4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

METTL7A also known as Methyltransferase-Like Protein 7A is an enzyme with a mass of approximately 24 kDa. It belongs to the methyltransferase family which affects the transfer of methyl groups to various substrates including proteins DNA and RNA. Expression of METTL7A occurs widely in human tissues with notable presence in the liver lung and adipose tissue. These characteristics suggest this protein plays a versatile role in diverse cellular processes across multiple systems in the body.
Biological function summary

METTL7A is important for maintaining cellular homeostasis and has a role in lipid metabolism. Although details about its association with specific protein complexes are limited METTL7A influences processes like lipid droplet formation and energy balance. Its expression levels indicate that it could affect the regulation of lipid accumulation and alterations may impact metabolic functions.

Pathways

Research reveals that METTL7A is involved in metabolic pathways pertinent to lipid and energy regulation. The protein is a part of the lipid metabolism pathway interacting with other proteins like PNPLA3 which is significant in lipid droplet biology. METTL7A interactions influence how cells store and manage lipids highlighting its importance in maintaining lipid equilibrium in cells.

METTL7A shows a connection to liver diseases and metabolic syndromes. Variations in METTL7A expression are linked to non-alcoholic fatty liver disease (NAFLD) where alterations in lipid droplet metabolism impact liver health. Relations with proteins like adiponectin suggest its involvement in broader metabolic conditions including obesity-related disorders. Consequently METTL7A remains a focus in studies aiming to comprehend and potentially treat these metabolic diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed : 37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed : 34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed : 34226523, PubMed : 34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed : 19773358).. (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.
See full target information TMT1A
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:759192 PubMed34790668

2021

miR-6807-5p Inhibited the Odontogenic Differentiation of Human Dental Pulp Stem Cells Through Directly Targeting METTL7A.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Wang,Xiao Han,Haoqing Yang,Dengsheng Xia,Zhipeng Fan

Cell death discovery 7:154 PubMed34226523

2021

Methyltransferase-like protein 7A (METTL7A) promotes cell survival and osteogenic differentiation under metabolic stress.

Applications

Unspecified application

Species

Unspecified reactive species

Eugene Lee,Ju-Young Kim,Tae-Kyung Kim,Seo-Young Park,Gun-Il Im

OncoTargets and therapy 9:5919-5929 PubMed27729801

2016

The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study.

Applications

Unspecified application

Species

Unspecified reactive species

Yong-Xu Jia,Teng-Fei Li,Dan-Dan Zhang,Zong-Min Fan,Hui-Jie Fan,Jie Yan,Li-Juan Chen,Hong Tang,Yan-Ru Qin,Xing-Ya Li
View all publications
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Product promise

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