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Rabbit Polyclonal MFAP4 antibody. Suitable for IHC - Wmt and reacts with Zebrafish samples. Immunogen corresponding to Recombinant Fragment Protein within Human MFAP4.

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Images

IHC - Wholemount - Anti-MFAP4 antibody (AB229543), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human MFAP4. The exact immunogen used to generate this antibody is proprietary information. Database link P55083

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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC - Wmt
Zebrafish
Tested

Tested
Tested

Species
Zebrafish
Dilution info
1/100 - 1/500
Notes

-

Associated Products

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Target data

Function

Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed:26601954).

Alternative names

Microfibril-associated glycoprotein 4, MFAP4

Recommended products

Rabbit Polyclonal MFAP4 antibody. Suitable for IHC - Wmt and reacts with Zebrafish samples. Immunogen corresponding to Recombinant Fragment Protein within Human MFAP4.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Recombinant Fragment Protein within Human MFAP4. The exact immunogen used to generate this antibody is proprietary information. Database link P55083
Purification technique
Affinity purification Immunogen
Concentration
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Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

MFAP4 also known as Microfibril-Associated Glycoprotein 4 is a protein that plays a significant role in the extracellular matrix architecture. The molecular mass of MFAP4 is about 29 kDa. This protein is expressed in various tissues including the lung liver heart and blood vessels. As a part of the extracellular matrix MFAP4 contributes to the structural integrity and elasticity of connective tissues.

Biological function summary

MFAP4 interacts with components of the microfibrillar network. It is not a standalone entity but functions as part of a larger complex that includes elastin and microfibrillin-1. This association enhances the mechanical properties of tissues maintaining them against pressure and stretch forces. MFAP4 also participates in cellular responses such as cell adhesion and migration which are critical for tissue remodeling and repair processes.

Pathways

MFAP4 engages in multiple biological pathways related to the extracellular matrix and tissue homeostasis. The TGF-beta signaling pathway is notable as MFAP4 interacts with multiple proteins within this pathway such as fibrillin-1. Through these interactions MFAP4 influences the regulation of cell growth and differentiation. Another pathway is the integrin signaling pathway where its association with integrins supports cell adhesion and communication within the extracellular matrix.

Associated diseases and disorders

MFAP4 shows associations with fibrosis and chronic obstructive pulmonary disease (COPD). Both conditions involve alterations in the extracellular matrix composition and function. In fibrosis the dysregulated expression of MFAP4 can affect connective tissue remodeling. Altered MFAP4 levels have also been observed in COPD where it may impact lung tissue elasticity. The protein connects with TGF-beta in the context of these diseases influencing abnormal tissue remodeling and inflammation processes.

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1 product image

  • IHC - Wholemount - Anti-MFAP4 antibody (ab229543), expandable thumbnail

    IHC - Wholemount - Anti-MFAP4 antibody (ab229543)

    2 days-post-fertilization zebrafish embryo stained for MFAP4 (green) using ab229543 at 1/100 dilution in whole mount immunohistochemical analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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