AB169757

Anti-MFAP4 antibody [EPR10254(B)]

RabMAb
Recombinant
What is this?

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(4 Publications)

Rabbit Recombinant Monoclonal MFAP4 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications.

View Alternative Names

Microfibril-associated glycoprotein 4, MFAP4

1 Images

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Western blot - Anti-MFAP4 antibody [EPR10254(B)] (AB169757)

All lanes:

Western blot - Anti-MFAP4 antibody [EPR10254(B)] (ab169757) at 1/1000 dilution

Lane 1:

Fetal spleen lysate at 10 µg

Lane 2:

Fetal kidney lysate at 10 µg

Lane 3:

Fetal lung lysate at 10 µg

Predicted band size: 29 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10254(B)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MFAP4 also known as Microfibril-Associated Glycoprotein 4 is a protein that plays a significant role in the extracellular matrix architecture. The molecular mass of MFAP4 is about 29 kDa. This protein is expressed in various tissues including the lung liver heart and blood vessels. As a part of the extracellular matrix MFAP4 contributes to the structural integrity and elasticity of connective tissues.

Biological function summary

MFAP4 interacts with components of the microfibrillar network. It is not a standalone entity but functions as part of a larger complex that includes elastin and microfibrillin-1. This association enhances the mechanical properties of tissues maintaining them against pressure and stretch forces. MFAP4 also participates in cellular responses such as cell adhesion and migration which are critical for tissue remodeling and repair processes.

Pathways

MFAP4 engages in multiple biological pathways related to the extracellular matrix and tissue homeostasis. The TGF-beta signaling pathway is notable as MFAP4 interacts with multiple proteins within this pathway such as fibrillin-1. Through these interactions MFAP4 influences the regulation of cell growth and differentiation. Another pathway is the integrin signaling pathway where its association with integrins supports cell adhesion and communication within the extracellular matrix.

MFAP4 shows associations with fibrosis and chronic obstructive pulmonary disease (COPD). Both conditions involve alterations in the extracellular matrix composition and function. In fibrosis the dysregulated expression of MFAP4 can affect connective tissue remodeling. Altered MFAP4 levels have also been observed in COPD where it may impact lung tissue elasticity. The protein connects with TGF-beta in the context of these diseases influencing abnormal tissue remodeling and inflammation processes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed : 26601954).

See full target information MFAP4

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:1403 PubMed41028852

2025

Targeting ALOX5 ameliorates renal tubular injury in ischemia-reperfusion-induced acute kidney injury via inhibition of ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Liming Huang,Qiao Tang,Guoli Li,Yanpei Hou,Sipei Chen,Qi Yao,Yanwen Luo,Lin Xiong,Yaling Zhang,Hongsha Yang,Li Wang,Guisen Li,Yi Li,Yunlin Feng

Discover oncology 16:1527 PubMed40788351

2025

Screening drugs of Anemoside B4 for MFAP4 expression in osteosarcoma in PDTX to increase personalized medicine.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhang,Lijuan Zeng,Jing Zhang,Zhiwei He,Xiaozhou Liu

International journal of molecular sciences 22: PubMed33919253

2021

Analysis of Astroglial Secretomic Profile in the Mecp2-Deficient Male Mouse Model of Rett Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Yann Ehinger,Valerie Matagne,Valérie Cunin,Emilie Borloz,Michel Seve,Sandrine Bourgoin-Voillard,Ana Borges-Correia,Laurent Villard,Jean-Christophe Roux

Arteriosclerosis, thrombosis, and vascular biology 39:1859-1873 PubMed31315432

2019

Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoke Yin 殷晓科,Shaynah Wanga,Adam L Fellows,Javier Barallobre-Barreiro,Ruifang Lu,Hongorzul Davaapil,Romy Franken,Marika Fava,Ferheen Baig,Philipp Skroblin,Qiuru Xing,David R Koolbergen,Maarten Groenink,Aeilko H Zwinderman,Ron Balm,Carlie J M de Vries,Barbara J M Mulder,Rosa Viner,Marjan Jahangiri,Dieter P Reinhardt,Sanjay Sinha,Vivian de Waard,Manuel Mayr

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MFAP4 antibody [EPR10254(B)]

Western blot - Anti-MFAP4 antibody [EPR10254(B)] (AB169757)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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