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AB117618

Anti-MFSD2A/NLS1 antibody

1

(2 Reviews)

|

(3 Publications)

Rabbit Polyclonal MFSD2A/NLS1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications.

View Alternative Names

MFSD2, NLS1, HMFN0656, PP9177, UNQ300/PRO341, MFSD2A, Sodium-dependent lysophosphatidylcholine symporter 1, Sodium-dependent LPC symporter 1, Major facilitator superfamily domain-containing protein 2A, HsMFSD2A, MFSD2a

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB117618)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB117618)

ab117618, at 5 μg/ml, staining MFSD2A/NLS1 in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB117618)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB117618)

ab117618, at 5 μg/ml, staining MFSD2A/NLS1 in Formalin-fixed, Paraffin-embedded Human Brain, Cerebellum tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB117618)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB117618)

ab117618, at 5 μg/ml, staining MFSD2A/NLS1 in Formalin-fixed, Paraffin-embedded Human Brain, Cortex tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Anti-MFSD2A/NLS1 antibody

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MFSD2A also known as Major Facilitator Superfamily Domain-Containing Protein 2A functions as a transporter protein. It efficiently facilitates transport of specific lipids across cellular membranes. This protein has a mass of approximately 56 kDa and is mainly expressed in the blood-brain barrier and endothelial cells. MFSD2A's expression in these areas plays an important role in transport through the protective barrier in the brain.
Biological function summary

MFSD2A is important in mediating uptake of omega-3 fatty acids such as docosahexaenoic acid (DHA) into the brain. It achieves this by ensuring proper distribution of lipids necessary for maintaining brain health and function. While not known to be a part of a larger complex MFSD2A works closely with lipid molecules and other membrane transporters to regulate lipid homeostasis within the brain.

Pathways

MFSD2A is involved in the lipid metabolic pathway and the neurovascular signaling pathway. Its activity significantly affects how lipids are transported and utilized within these systems. It interacts functionally with proteins like ABC transporters which also contribute to lipid processing and transport. These pathways highlight the importance of MFSD2A in lipid utilization and brain metabolism.

MFSD2A is closely linked to neurological conditions such as microcephaly and certain neurodevelopmental disorders. Its malfunction or altered expression can disrupt the supply of essential lipids to the brain leading to developmental abnormalities. The protein's role connects to other transporters like FABP5 hinting at a network of lipid transport mechanisms that when altered contribute to these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed : 24828040, PubMed : 32572202, PubMed : 34135507). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed : 26005868, PubMed : 34135507). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed : 21677192). In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed : 18988732, PubMed : 23177091).
See full target information MFSD2A
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer communications (London, England) 43:1097-1116 PubMed37539769

2023

MFSD2A potentiates gastric cancer response to anti-PD-1 immunotherapy by reprogramming the tumor microenvironment to activate T cell response.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Zhang,Chun-Mei Wang,Hao-Xiang Wu,Feng Wang,Yang-Yang Chai,Ye Hu,Bing-Jing Wang,Zhou Yu,Rong-Hua Xia,Rui-Hua Xu,Xue-Tao Cao

Molecular therapy : the journal of the American Society of Gene Therapy 30:1275-1287 PubMed34763084

2021

Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenguo Yang,Cheng Huang,Xueyi Wen,Wenlin Liu,Xiaoxiong Huang,Yufeng Li,Jiankun Zang,Zean Weng,Dan Lu,Chi Kwan Tsang,Keshen Li,Anding Xu

Molecular therapy. Nucleic acids 4:e262 PubMed26528939

2015

In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin.

Applications

Unspecified application

Species

Unspecified reactive species

Delphine Laustriat,Jacqueline Gide,Laetitia Barrault,Emilie Chautard,Clara Benoit,Didier Auboeuf,Anne Boland,Christophe Battail,François Artiguenave,Jean-François Deleuze,Paule Bénit,Pierre Rustin,Sylvia Franc,Guillaume Charpentier,Denis Furling,Guillaume Bassez,Xavier Nissan,Cécile Martinat,Marc Peschanski,Sandrine Baghdoyan
View all publications
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Product promise

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