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AB217970

Anti-MFSD2A/NLS1 antibody

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(1 Publication)

Rabbit Polyclonal MFSD2A/NLS1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MFSD2A aa 300-400 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

MFSD2, NLS1, HMFN0656, PP9177, UNQ300/PRO341, MFSD2A, Sodium-dependent lysophosphatidylcholine symporter 1, Sodium-dependent LPC symporter 1, Major facilitator superfamily domain-containing protein 2A, HsMFSD2A, MFSD2a

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB217970)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB217970)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human larynx tissue labeling MFSD2A/NLS1 with ab217970 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB217970)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB217970)

Immunohistochemical analysis of paraformaldehyde-fixed and paraffin-embedded Human liver carcinoma tissue labeling MFSD2A/NLS1 with ab217970 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB217970)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MFSD2A/NLS1 antibody (AB217970)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human placenta tissue labeling MFSD2A/NLS1 with ab217970 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MFSD2A aa 300-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8NA29

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MFSD2A also known as Major Facilitator Superfamily Domain-Containing Protein 2A functions as a transporter protein. It efficiently facilitates transport of specific lipids across cellular membranes. This protein has a mass of approximately 56 kDa and is mainly expressed in the blood-brain barrier and endothelial cells. MFSD2A's expression in these areas plays an important role in transport through the protective barrier in the brain.
Biological function summary

MFSD2A is important in mediating uptake of omega-3 fatty acids such as docosahexaenoic acid (DHA) into the brain. It achieves this by ensuring proper distribution of lipids necessary for maintaining brain health and function. While not known to be a part of a larger complex MFSD2A works closely with lipid molecules and other membrane transporters to regulate lipid homeostasis within the brain.

Pathways

MFSD2A is involved in the lipid metabolic pathway and the neurovascular signaling pathway. Its activity significantly affects how lipids are transported and utilized within these systems. It interacts functionally with proteins like ABC transporters which also contribute to lipid processing and transport. These pathways highlight the importance of MFSD2A in lipid utilization and brain metabolism.

MFSD2A is closely linked to neurological conditions such as microcephaly and certain neurodevelopmental disorders. Its malfunction or altered expression can disrupt the supply of essential lipids to the brain leading to developmental abnormalities. The protein's role connects to other transporters like FABP5 hinting at a network of lipid transport mechanisms that when altered contribute to these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed : 24828040, PubMed : 32572202, PubMed : 34135507). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed : 26005868, PubMed : 34135507). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed : 21677192). In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed : 18988732, PubMed : 23177091).
See full target information MFSD2A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 12:781247 PubMed35356205

2022

P38 Mitogen-Activated Protein Kinase Protects Against Retinoblastoma Through Regulating USP22/SIRT1/SOST Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoming Huang,Jianfeng Wan,Fei Liu,Yang Liu,Lina Wang,Sidi Zhao,Tong Wu,Fengyuan Sun
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Product promise

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