Anti-mGluR1 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

MGluR1 contributes to synaptic plasticity a critical process for learning and memory. It forms part of a signaling complex that interacts with several other proteins including Homer proteins which facilitate the link to intracellular calcium release channels. The receptor's activation leads to a cascade of intracellular events including the mobilization of calcium and activation of various kinases. These processes subsequently affect long-term potentiation and depression which are key for adaptable and responsive neural circuits.

Pathways

MGluR1 operates within important signaling pathways such as the phosphoinositide pathway and the MAPK/ERK pathway. In the phosphoinositide pathway it activates phospholipase C which results in the production of inositol trisphosphate and diacylglycerol second messengers that regulate calcium release and protein kinase C activation respectively. Within the MAPK/ERK pathway mGluR1 activation contributes to gene expression changes through ERK activation influencing cellular responses and adaptations. Proteins such as calcium-calmodulin and GRK2 are related to mGluR1 within these pathways impacting receptor sensitivity and function.