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AB233791

Anti-MGLUR8 antibody [4C1C1]

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(1 Publication)

Mouse Monoclonal MGLUR8 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRM8 aa 400-600.

View Alternative Names

GPRC1H, MGLUR8, GRM8, Metabotropic glutamate receptor 8, mGluR8

3 Images
Western blot - Anti-MGLUR8 antibody [4C1C1] (AB233791)
  • WB

Supplier Data

Western blot - Anti-MGLUR8 antibody [4C1C1] (AB233791)

Expected MW is 42.6 kDa.

All lanes:

Western blot - Anti-MGLUR8 antibody [4C1C1] (ab233791) at 1/500 dilution

All lanes:

Human MGLUR8 (aa 440-583) recombinant protein

Predicted band size: 102 kDa

false

Western blot - Anti-MGLUR8 antibody [4C1C1] (AB233791)
  • WB

Supplier Data

Western blot - Anti-MGLUR8 antibody [4C1C1] (AB233791)

Lanes 1 - 2:

Western blot - Anti-MGLUR8 antibody [4C1C1] (ab233791) at 1/500 dilution

Lanes 1 - 2:

Western blot - Anti-TLL1 antibody [4H8C1] (<a href='/en-us/products/primary-antibodies/tll1-antibody-4h8c1-ab233827'>ab233827</a>)

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) whole cell lysate

Lane 2:

TLL1 (AA: 870-1013)-hIgGFc transfected HEK-293 whole cell lysate

Predicted band size: 102 kDa,115 kDa

true

Flow Cytometry - Anti-MGLUR8 antibody [4C1C1] (AB233791)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-MGLUR8 antibody [4C1C1] (AB233791)

Flow cytometric analysis of SK-N-SH (human neuroblastoma cell line) cells labeling MGLUR8 with ab233791 at 1/200 dilution (green) compared with a negative control (red).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

4C1C1

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human GRM8 aa 400-600. The exact immunogen used to generate this antibody is proprietary information.

O00222

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from tissue culture supernatant.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The metabotropic glutamate receptor 8 (mGluR8) also known as GRM8 is a G-protein coupled receptor with an approximate molecular mass of 105 kDa. This receptor is involved in neurotransmitter signaling and plays a significant role in synaptic transmission by regulating the release of neurotransmitters. mGluR8 is mostly expressed in the brain specifically in regions related to sensory perception and modulation such as the retina olfactory bulb and various other brain areas.
Biological function summary

MGluR8 impacts neuronal excitability by modulating synaptic plasticity. It is often found as part of a dimerized complex with other mGluR proteins affecting intracellular signaling cascades. The receptor functions largely through inhibition of the cyclic AMP pathway making it a critical regulator in glutamatergic signaling. mGluR8’s activity serves as an important control point for maintaining the balance of excitatory neurotransmission within the central nervous system.

Pathways

MGluR8 is intricately connected to glutamatergic synaptic transmission and the cAMP signaling pathway. Through its role in these pathways mGluR8 interacts with proteins such as adenylate cyclase and other mGluR family members modulating downstream signaling events. These interactions position mGluR8 as an important element in neural communication processes influencing learning and memory functions.

MGluR8 has been associated with neurodegenerative diseases like Alzheimer's and psychiatric disorders such as anxiety. Its regulatory role in glutamatergic neurotransmission links it to pathologies characterized by excitotoxicity and altered synaptic plasticity. Interactions between mGluR8 and other proteins like presenilin-1 in Alzheimer's disease shed light on its potential as a therapeutic target for modulating disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
See full target information GRM8
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Kidney international 81:458-68 PubMed22166849

2011

Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Leyi Gu,Xinyue Liang,Lihua Wang,Yucheng Yan,Zhaohui Ni,Huili Dai,Jiayuan Gao,Shan Mou,Qin Wang,Xinyu Chen,Liming Wang,Jiaqi Qian
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB53094

Anti-MGLUR8 antibody

primary-antibodies

mglur8-antibody-ab53094

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