Anti-MGO-modified proteins antibody [MGO-1]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Proteins that undergo MGO modification can disrupt cellular processes and reduce protein stability. These altered proteins fail to perform their typical functions leading to impairment in protein regulation and cellular signaling. MGO itself does not form part of a complex but its frequent involvement with AGEs allows it to extensively influence cellular mechanisms. The accumulation of MGO-modified proteins can result in oxidative stress and apoptosis in cells further affecting cellular health and functionality.

Pathways

MGO-modified proteins are significantly involved in oxidative stress and the glyoxalase system which detoxifies methylglyoxal using the enzymes glyoxalase I and II. This pathway helps maintain cellular homeostasis by preventing excessive accumulation of MGO and its associated AGEs. MGO-related modifications also play a role in several metabolic pathways impacting proteins like glutathione which is critical for detoxifying reactive species and maintaining redox balance. Their interaction can potentially disrupt normal cellular function if not properly managed.