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AB224367

Anti-MGP antibody

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(2 Publications)

Rabbit Polyclonal MGP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MGP aa 1-100.

View Alternative Names

MGLAP, GIG36, MGP, Matrix Gla protein, Cell growth-inhibiting gene 36 protein

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MGP antibody (AB224367)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MGP antibody (AB224367)

Paraffin-embedded human nasopharynx tissue stained for MGP using ab224367 at 1/200 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MGP aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P08493

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Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MGP protein also known as Matrix Gla Protein is a secreted protein that has a molecular mass of approximately 10 kDa. It is expressed in the cartilage bone and vasculature where it plays a significant role in inhibiting calcification. MGP undergoes gamma-carboxylation a post-translational modification that is important for its function in the extracellular matrix. This modification allows MGP to bind calcium ions preventing mineral deposition in the vascular tissues. Alongside its role in bone health MGP acts as an antagonist against vascular calcification.
Biological function summary

MGP regulates extracellular matrix mineralization playing an important part in maintaining tissue integrity. It is not part of a simple complex structure but interacts with other extracellular matrix components like osteopontin. The function of MGP in bone and tissue health highlights its protective roles against pathological calcification. Defective or insufficient MGP leads to increased calcification contributing to its important role in keeping arteries flexible and functional.

Pathways

MGP interacts within the BMP signaling pathway where it modulates bone morphogenetic proteins to prevent inappropriate ossification. It also participates in the regulation of the vitamin K-dependent carboxylation pathway critical for activating MGP's calcification inhibitory function. Related proteins in the pathways include osteocalcin which also undergoes similar gamma-carboxylation and fetuin-A another calcification inhibitor. MGP's effect on these pathways showcases its pivotal role in tissue and vascular health.

MGP has connections to arteriosclerosis and Keutel syndrome where abnormal calcification is a common feature. In arteriosclerosis MGP deficiency can lead to inappropriate calcification of the arteries complicating cardiovascular health. Keutel syndrome a rare genetic disorder results from mutations in the MGP gene causing abnormal calcification primarily in cartilage. Through these disease associations connections to proteins like osteocalcin highlight the importance of MGP in preventing pathological calcifications and preserving normal tissue function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
See full target information MGP
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:110537 PubMed39193188

2024

Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Stephen J Gadomski,Byron W H Mui,Raphael Gorodetsky,Sriram S Paravastu,Joseph Featherall,Li Li,Abigail Haffey,Jae-Chun Kim,Sergei A Kuznetsov,Kathryn Futrega,Astar Lazmi-Hailu,Randall K Merling,Daniel Martin,Andrew W McCaskie,Pamela G Robey

Aging 13:22109-22119 PubMed34536269

2021

LHX9, a p53-binding protein, inhibits the progression of glioma by suppressing glycolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangying Luo,Jianwei Ge,Tao Chen,Jinfang Liu,Ziyuan Liu,Changlong Bi,Song Lan
View all publications
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Product promise

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