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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal MGP antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MGP aa 1-100.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Orangutan | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Orangutan | Dilution info - | Notes - |
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Matrix Gla protein, MGP, Cell growth-inhibiting gene 36 protein, GIG36, MGLAP, MGP
Rabbit Polyclonal MGP antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MGP aa 1-100.
Matrix Gla protein, MGP, Cell growth-inhibiting gene 36 protein, GIG36, MGLAP, MGP
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
MGP regulates extracellular matrix mineralization playing an important part in maintaining tissue integrity. It is not part of a simple complex structure but interacts with other extracellular matrix components like osteopontin. The function of MGP in bone and tissue health highlights its protective roles against pathological calcification. Defective or insufficient MGP leads to increased calcification contributing to its important role in keeping arteries flexible and functional.
The MGP protein also known as Matrix Gla Protein is a secreted protein that has a molecular mass of approximately 10 kDa. It is expressed in the cartilage bone and vasculature where it plays a significant role in inhibiting calcification. MGP undergoes gamma-carboxylation a post-translational modification that is important for its function in the extracellular matrix. This modification allows MGP to bind calcium ions preventing mineral deposition in the vascular tissues. Alongside its role in bone health MGP acts as an antagonist against vascular calcification.
MGP interacts within the BMP signaling pathway where it modulates bone morphogenetic proteins to prevent inappropriate ossification. It also participates in the regulation of the vitamin K-dependent carboxylation pathway critical for activating MGP's calcification inhibitory function. Related proteins in the pathways include osteocalcin which also undergoes similar gamma-carboxylation and fetuin-A another calcification inhibitor. MGP's effect on these pathways showcases its pivotal role in tissue and vascular health.
MGP has connections to arteriosclerosis and Keutel syndrome where abnormal calcification is a common feature. In arteriosclerosis MGP deficiency can lead to inappropriate calcification of the arteries complicating cardiovascular health. Keutel syndrome a rare genetic disorder results from mutations in the MGP gene causing abnormal calcification primarily in cartilage. Through these disease associations connections to proteins like osteocalcin highlight the importance of MGP in preventing pathological calcifications and preserving normal tissue function.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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Terms & Conditions.
Paraffin-embedded human nasopharynx tissue stained for MGP using ab224367 at 1/200 dilution in immunohistochemical analysis.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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