Rabbit Polyclonal MIA2 antibody. Carrier free. Suitable for sELISA, WB and reacts with Recombinant full length protein - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MIA2.
Constituents: PBS
| sELISA | WB | |
|---|---|---|
| Human | Predicted | Predicted |
| Recombinant full length protein - Human | Tested | Tested |
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info 0.5-2 µg/mL | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info 0.1-0.2 µg/mL | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179).
CTAGE5, MEA11, MEA6, MGEA11, MGEA6, MIA2, Melanoma inhibitory activity protein 2, MIA protein 2, CTAGE family member 5 ER export factor, Cutaneous T-cell lymphoma-associated antigen 5, Meningioma-expressed antigen 6/11
Rabbit Polyclonal MIA2 antibody. Carrier free. Suitable for sELISA, WB and reacts with Recombinant full length protein - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MIA2.
Constituents: PBS
Although some customers have been successful in IHC we no longer batch test in this application.
The MIA2 protein also known as Melanoma Inhibitory Activity 2 weighs approximately 95 kDa. It belongs to the MIA gene family and shows high expression in liver tissues. MIA2 participates in the regulation of cell adhesion and extracellular matrix interactions. Its presence is also observed in other tissues but not as strongly as in the liver where it works closely with cellular processes involving protein secretion.
MIA2 influences cell signaling mechanisms including proliferation and migration. It does not form part of a known large macromolecular complex but still plays a significant role in secretion pathways. Researchers believe its interactions with cellular membranes and extracellular matrix components are important for understanding how cells communicate and respond to their environment.
MIA2 participates in the insulin signaling pathway and ERK/MAPK pathway. These pathways impact cellular growth and metabolism. MIA2 interacts alongside proteins in these pathways like the insulin receptor and various growth factors influencing cellular functions through these pathways in specific cells like hepatocytes and others.
MIA2 is relevant to hepatocellular carcinoma and liver fibrosis. Changes in MIA2 expression correlate with the progression of these diseases. The protein is also connected to the fibrotic processes through the interaction with collagen-related proteins which impact extracellular matrix formation and degradation highlighting its role in the pathophysiology of liver-related disorders.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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