AB58973

Anti-MIA2 antibody

Name: Anti-MIA2 antibody (ab58973) | Abcam
Brand: Abcam Limited
SKU: AB58973

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(3 Publications)

Rabbit Polyclonal MIA2 antibody. Carrier free. Suitable for sELISA, WB and reacts with Recombinant full length protein - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MIA2.

View Alternative Names

CTAGE5, MEA11, MEA6, MGEA11, MGEA6, MIA2, Melanoma inhibitory activity protein 2, MIA protein 2, CTAGE family member 5 ER export factor, Cutaneous T-cell lymphoma-associated antigen 5, Meningioma-expressed antigen 6/11

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MIA2.

Q96PC5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "predicted", "sELISA-species-dilution-info": "", "sELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant full length protein - Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "0.5-2 µg/mL", "sELISA-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.2 µg/mL", "WB-species-notes": "<p></p>" } } }

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Product details

Although some customers have been successful in IHC we no longer batch test in this application.

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Properties and storage information

Form

Lyophilized

Reconstitution

Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml

Purification technique

Affinity purification Immunogen

Storage buffer

Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MIA2 protein also known as Melanoma Inhibitory Activity 2 weighs approximately 95 kDa. It belongs to the MIA gene family and shows high expression in liver tissues. MIA2 participates in the regulation of cell adhesion and extracellular matrix interactions. Its presence is also observed in other tissues but not as strongly as in the liver where it works closely with cellular processes involving protein secretion.

Biological function summary

MIA2 influences cell signaling mechanisms including proliferation and migration. It does not form part of a known large macromolecular complex but still plays a significant role in secretion pathways. Researchers believe its interactions with cellular membranes and extracellular matrix components are important for understanding how cells communicate and respond to their environment.

Pathways

MIA2 participates in the insulin signaling pathway and ERK/MAPK pathway. These pathways impact cellular growth and metabolism. MIA2 interacts alongside proteins in these pathways like the insulin receptor and various growth factors influencing cellular functions through these pathways in specific cells like hepatocytes and others.

MIA2 is relevant to hepatocellular carcinoma and liver fibrosis. Changes in MIA2 expression correlate with the progression of these diseases. The protein is also connected to the fibrotic processes through the interaction with collagen-related proteins which impact extracellular matrix formation and degradation highlighting its role in the pathophysiology of liver-related disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed : 21525241, PubMed : 25202031, PubMed : 27138255, PubMed : 27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed : 27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed : 21525241, PubMed : 25202031, PubMed : 27170179).

See full target information MIA2

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

American journal of cancer research 12:2833-2849 PubMed35812061

2022

CircNRIP1 acts as a sponge of miR-1200 to suppress osteosarcoma progression via upregulation of MIA2.

Applications

Unspecified application

Species

Unspecified reactive species

Ruoxuan Hei,Jinnan Chen,Xiaojing Zhang,Huiqin Bian,Chen Chen,Xuan Wu,Tiaotiao Han,Yiming Zhang,Junxia Gu,Yaojuan Lu,Qiping Zheng

International journal of oncology 56:1093-1100 PubMed32319583

2020

Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Miyako Kurihara-Shimomura,Tomonori Sasahira,Hiroyuki Shimomura,Anja Katrin Bosserhoff,Tadaaki Kirita

Biochemical and biophysical research communication 416:379-84 PubMed22120627

2011

The X protein of hepatitis B virus activates hepatoma cell proliferation through repressing melanoma inhibitory activity 2 gene.

Applications

sELISA

Species

Unspecified reactive species

Yilin Xu,Yang Yang,Yanyan Cai,Fang Liu,Yingle Liu,Ying Zhu,Jianguo Wu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MIA2 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Reconstitution

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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