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Goat Polyclonal MICU1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MICU1 aa 100-150.


Images

Key facts

Isotype

IgG

Host species

Goat

Storage buffer

pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human MICU1 aa 100-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BPX6
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Mouse
Predicted
Predicted
Rat
Predicted
Predicted
Chicken
Predicted
Predicted
Cow
Predicted
Predicted
Cynomolgus monkey
Predicted
Predicted
Dog
Predicted
Predicted
Goat
Predicted
Predicted
Hamster
Predicted
Predicted
Horse
Predicted
Predicted
Pig
Predicted
Predicted
Rabbit
Predicted
Predicted
Xenopus tropicalis
Predicted
Predicted
Zebrafish
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

0.50000-2.00000 µg/mL

Notes

-

Predicted
Predicted

Species

Mouse, Rat, Rabbit, Goat, Horse, Chicken, Hamster, Cow, Dog, Pig, Zebrafish, Cynomolgus monkey, Xenopus tropicalis

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

3.75 µg/mL

Notes

-

Predicted
Predicted

Species

Mouse, Rat, Rabbit, Goat, Horse, Chicken, Hamster, Cow, Dog, Pig, Zebrafish, Cynomolgus monkey, Xenopus tropicalis

Dilution info

-

Notes

-

Target data

Function

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

Alternative names

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Goat Polyclonal MICU1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MICU1 aa 100-150.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human MICU1 aa 100-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BPX6
Purification technique

Affinity purification Immunogen

Specificity

ab190114 is expected to recognize reported isoforms 1 and 2 (NP_006068.2; NP_001182447.1).

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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2 product images

  • Western blot - Anti-MICU1 antibody (ab190114), expandable thumbnail

    Western blot - Anti-MICU1 antibody (ab190114)

    Primary incubation was 1 hour.

    An additional band of unknown identity was also consistently observed at 37 kDa. This band was successfully blocked by incubation with the immunizing peptide.

    All lanes: Western blot - Anti-MICU1 antibody (AB190114) at 0.5 µg/mL

    All lanes: K562 lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 54 kDa

    Observed band size: 55 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MICU1 antibody (ab190114), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MICU1 antibody (ab190114)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung, respiratory epithelium labeling MICU1 with ab190114 at 3.75 μg/ml.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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