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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Goat Polyclonal MICU1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MICU1 aa 100-150.
IgG
Goat
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Liquid
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Tested | Tested |
Mouse | Predicted | Predicted |
Rat | Predicted | Predicted |
Chicken | Predicted | Predicted |
Cow | Predicted | Predicted |
Cynomolgus monkey | Predicted | Predicted |
Dog | Predicted | Predicted |
Goat | Predicted | Predicted |
Hamster | Predicted | Predicted |
Horse | Predicted | Predicted |
Pig | Predicted | Predicted |
Rabbit | Predicted | Predicted |
Xenopus tropicalis | Predicted | Predicted |
Zebrafish | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.50000-2.00000 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Rabbit, Goat, Horse, Chicken, Hamster, Cow, Dog, Pig, Zebrafish, Cynomolgus monkey, Xenopus tropicalis | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 3.75 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Rabbit, Goat, Horse, Chicken, Hamster, Cow, Dog, Pig, Zebrafish, Cynomolgus monkey, Xenopus tropicalis | Dilution info - | Notes - |
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).
Atopy-related autoantigen CALC, Calcium-binding atopy-related autoantigen 1, ara CALC, CALC, CBARA1, MICU1
Goat Polyclonal MICU1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MICU1 aa 100-150.
Atopy-related autoantigen CALC, Calcium-binding atopy-related autoantigen 1, ara CALC, CALC, CBARA1, MICU1
IgG
Goat
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Liquid
Polyclonal
Affinity purification Immunogen
ab190114 is expected to recognize reported isoforms 1 and 2 (NP_006068.2; NP_001182447.1).
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Terms & Conditions.
Primary incubation was 1 hour.
An additional band of unknown identity was also consistently observed at 37 kDa. This band was successfully blocked by incubation with the immunizing peptide.
All lanes: Western blot - Anti-MICU1 antibody (AB190114) at 0.5 µg/mL
All lanes: K562 lysate (in RIPA buffer) at 35 µg
Developed using the ECL technique.
Predicted band size: 54 kDa
Observed band size: 55 kDa
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung, respiratory epithelium labeling MICU1 with ab190114 at 3.75 μg/ml.
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