Mouse Polyclonal MIIP antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MIIP.
Images
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human MIIP. Database link Q5JXC2
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
Target data
Function
Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.
Alternative names
IIP45, MIIP, Migration and invasion-inhibitory protein, IGFBP2-binding protein, Invasion-inhibitory protein 45, IIp45
Recommended products
Mouse Polyclonal MIIP antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MIIP.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human MIIP. Database link Q5JXC2
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MIIP also known as Migration and Invasion Inhibitory Protein is a protein with a mass of approximately 47 kDa. It acts mechanically as an important regulator of cellular movement and invasion processes. MIIP expression occurs in various tissues including the brain and reproductive organs. Scientists recognize MIIP for its role in modulating cytoskeletal dynamics and protein interactions that affect cell motility.
- Biological function summary
MIIP plays a significant role in inhibiting cell migration and invasion contributing to its function as a tumor suppressor. It interacts with important components of the cytoskeletal network and may work together with other proteins to form complexes that stabilize actin filaments. Through these interactions MIIP helps control cellular structure integrity and movement impacting the invasive potential of cells.
- Pathways
MIIP impacts several key signaling pathways. It integrates into the PI3K/AKT signaling pathway which influences cell survival and proliferation. This protein also interacts within the Wnt/β-catenin pathway known for its role in cell growth and development. MIIP's association with these pathways links it to interactions with proteins like AKT and β-catenin creating a regulatory network that balances normal and pathological cell behavior.
- Associated diseases and disorders
MIIP is associated with cancer and its progression. Studies have shown that reduced MIIP expression correlates with increased tumor invasiveness and metastasis particularly in gliomas and breast cancer. In these contexts MIIP interacts with proteins such as matrix metalloproteinases (MMPs) which aid in tissue invasion. By inhibiting these interactions MIIP exerts a protective effect against tumor progression highlighting its potential as a therapeutic target.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-MIIP antibody (ab167197)
All lanes: Western blot - Anti-MIIP antibody (ab167197) at 1 µg/mL
Lane 1: Lysate of 293T cells transfected with MIIP at 15 µL
Lane 2: Lysate of 293T cells (non-transfected) at 15 µL
SecondaryAll lanes: Goat anti-mouse HRP conjugated antibody at 1/2500 dilution
Predicted band size: 43 kDa
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Product protocols
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