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AB204127

Anti-MIM antibody

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(3 Publications)

Rabbit Polyclonal MIM antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MTSS1 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

KIAA0429, MIM, MTSS1, Protein MTSS 1, Metastasis suppressor YGL-1, Metastasis suppressor protein 1, Missing in metastasis protein

1 Images
Western blot - Anti-MIM antibody (AB204127)
  • WB

Supplier Data

Western blot - Anti-MIM antibody (AB204127)

All lanes:

Western blot - Anti-MIM antibody (ab204127) at 1/300 dilution

All lanes:

mouse testicular lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP at 1/5000 dilution

Predicted band size: 82 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MTSS1 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O43312

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target MIM also known as Missing in Metastasis or MTSS1 plays an important role in cellular structure and signaling mechanics. MIM a protein with an approximate mass of 72 kDa interacts with the actin cytoskeleton to facilitate the remodelling of cell shape and movement. This protein is largely expressed in tissues such as the prostate breast and bladder. Its presence shows reduction in metastatic cancer cells explaining its role in controlling cell adhesion and movement.
Biological function summary

Missing in Metastasis functions in actin-binding processes and serves as an important player in cellular signal transduction mechanisms. MIM associates with other cellular components forming complexes that stabilize the actin cytoskeleton. It modulates the signaling pathways by interacting with proteins like Cortactin influencing cellular events such as migration and invasiveness. This protein's interactions strongly suggest a role in maintaining cellular integrity and suppressing metastatic behaviors.

Pathways

Researchers link Missing in Metastasis to signaling pathways controlling cell growth and movement like the Wnt signaling pathway and actin polymerization. It collaborates closely with proteins like Profilin 1 and suppresses Wiskott-Aldrich Syndrome Protein (WASP) which play significant roles in these biological pathways. MIM’s involvement in these pathways underlines its function in balancing cellular dynamics and influencing cellular responses.

Studies have extensively associated Missing in Metastasis with various cancers especially bladder and breast cancers. In these diseases MIM expression often correlates with suppressed metastasis highlighting a potential therapeutic angle. Additionally MIM interacts with oncogenic proteins such as ERBB2 in breast cancer identifying its role in tumor suppression pathways. Better understanding MIM’s relationships with these proteins and diseases suggests pathways for future therapeutic development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
See full target information MTSS1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Immunity, inflammation and disease 10:e686 PubMed36039648

2022

Positive association of serum FUT8 activity with renal tubulointerstitial injury in IgA nephropathy patients.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Yang,Long-Kai Li,Hui He,Xia-Nan Guo,Xue-Feng Yuan,Zhi-Tong Li,Wei-Dong Wang,Biao-Jie Qin,Xiang-Ning Du,Xu Zhang,Shu-Ni Chen,Hong-Li Lin

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 41:47-59 PubMed35695651

2022

Exosomal circRNA_104948 Enhances the Progression of Glioma by Regulating miR-29b-3p and DNMT3B/MTSS1 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Shoudan Zhang,Ning Guan,Xin Mao,Jingwen Cui,Xin Sui,Wenshi Guo

International journal of molecular medicine 47: PubMed33649808

2021

MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Chen,Qiang Chen,Yongyou Wu,Minggao Zhu,Jia Hu,Zhixiang Zhuang
View all publications
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