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AB127034

Anti-Mitochondrial ribosomal protein L11 antibody

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(1 Publication)

Rabbit Polyclonal Mitochondrial ribosomal protein L11 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MRPL11 aa 1-150.

View Alternative Names

CGI-113, MRPL11, Large ribosomal subunit protein uL11m, L11mt, MRP-L11

1 Images
Western blot - Anti-Mitochondrial ribosomal protein L11 antibody (AB127034)
  • WB

Unknown

Western blot - Anti-Mitochondrial ribosomal protein L11 antibody (AB127034)

12% SDS-PAGE

All lanes:

Western blot - Anti-Mitochondrial ribosomal protein L11 antibody (ab127034) at 1/1000 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 21 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human MRPL11 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q9Y3B7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Mitochondrial ribosomal protein L11 often called MRPL11 forms an important part of the mitochondrial ribosome or mitoribosome which plays an important role in protein synthesis within the mitochondria. MRPL11 has a mass of approximately 21.3 kDa and is expressed in tissues with high metabolic activity such as the heart and skeletal muscles. It differs from proteins found in the cytosolic ribosomes due to variations in protein to rRNA ratio and the presence of specific mitochondrial sequences.
Biological function summary

This protein contributes to the formation and functional stability of the large subunit of the mitochondrial ribosome. MRPL11 is an integral part of the mitoribosomal complex and it collaborates closely with mitochondrial ribosome protein L10 and L12. The assembly of these proteins ensures efficient mitochondrial translation which subsequently impacts mitochondrial energy production and apoptotic signaling.

Pathways

MRPL11 is deeply embedded in mitochondrial translation and oxidative phosphorylation pathways. These pathways are essential for cellular energy production and metabolism. MRPL11 interacts with other mitochondrial proteins such as mRNA encoders and enzymes in the electron transport chain. It ensures correct assembly and function of the mitochondrial machinery influencing energy demands through the connection to translation regulation and metabolic balance.

MRPL11 is associated with mitochondrial disorders like mitochondrial myopathy and neurodegenerative diseases. Mutations or dysregulations in MRPL11 can impair mitochondrial translation leading to compromised energy metabolism. Its dysfunction can involve other mitochondrial proteins such as those forming the electron transport chain or involved in cardiolipin metabolism contributing to the disease mechanisms. Understanding MRPL11's role offers insights into therapeutic targets for disease intervention in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information MRPL11
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 134: PubMed39286971

2024

SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyan Ren,Weiqi Hong,Jingyun Yang,Jun Zou,Li Chen,Yanan Zhou,Hong Lei,Aqu Alu,Haiying Que,Yanqiu Gong,Zhenfei Bi,Cai He,Minyang Fu,Dandan Peng,Yun Yang,Wenhai Yu,Cong Tang,Qing Huang,Mengli Yang,Bai Li,Jingmei Li,Junbin Wang,Xuelei Ma,Hongbo Hu,Wei Cheng,Haohao Dong,Jian Lei,Lu Chen,Xikun Zhou,Jiong Li,Wei Wang,Guangwen Lu,Guobo Shen,Li Yang,Jinliang Yang,Zhenling Wang,Guowen Jia,Zhaoming Su,Bin Shao,Hanpei Miao,Johnson Yiu-Nam Lau,Yuquan Wei,Kang Zhang,Lunzhi Dai,Shuaiyao Lu,Xiawei Wei
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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