Anti-Mitochondrial ribosomal protein L11 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Mitochondrial ribosomal protein L11 often called MRPL11 forms an important part of the mitochondrial ribosome or mitoribosome which plays an important role in protein synthesis within the mitochondria. MRPL11 has a mass of approximately 21.3 kDa and is expressed in tissues with high metabolic activity such as the heart and skeletal muscles. It differs from proteins found in the cytosolic ribosomes due to variations in protein to rRNA ratio and the presence of specific mitochondrial sequences.

Biological function summary

This protein contributes to the formation and functional stability of the large subunit of the mitochondrial ribosome. MRPL11 is an integral part of the mitoribosomal complex and it collaborates closely with mitochondrial ribosome protein L10 and L12. The assembly of these proteins ensures efficient mitochondrial translation which subsequently impacts mitochondrial energy production and apoptotic signaling.

Pathways

MRPL11 is deeply embedded in mitochondrial translation and oxidative phosphorylation pathways. These pathways are essential for cellular energy production and metabolism. MRPL11 interacts with other mitochondrial proteins such as mRNA encoders and enzymes in the electron transport chain. It ensures correct assembly and function of the mitochondrial machinery influencing energy demands through the connection to translation regulation and metabolic balance.

Associated diseases and disorders

MRPL11 is associated with mitochondrial disorders like mitochondrial myopathy and neurodegenerative diseases. Mutations or dysregulations in MRPL11 can impair mitochondrial translation leading to compromised energy metabolism. Its dysfunction can involve other mitochondrial proteins such as those forming the electron transport chain or involved in cardiolipin metabolism contributing to the disease mechanisms. Understanding MRPL11's role offers insights into therapeutic targets for disease intervention in these conditions.