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AB93323

Anti-Mitofilin antibody

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(4 Publications)

Rabbit Polyclonal Mitofilin antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IMMT.

View Alternative Names

HMP, MIC60, MINOS2, PIG4, PIG52, IMMT, MICOS complex subunit MIC60, Cell proliferation-inducing gene 4/52 protein, Mitochondrial inner membrane protein, Mitofilin, p87/89

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-Mitofilin antibody (AB93323)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Mitofilin antibody (AB93323)

Immunofluorescent analysis of Mitofilin using anti-Mitofilin polyclonal antibody (ab93323) shows staining in A549 Cells.

Immunocytochemistry/ Immunofluorescence - Anti-Mitofilin antibody (AB93323)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Mitofilin antibody (AB93323)

Immunofluorescent analysis of Mitofilin using anti-Mitofilin polyclonal antibody (ab93323) shows staining in HMVEC Cells.

Immunocytochemistry/ Immunofluorescence - Anti-Mitofilin antibody (AB93323)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Mitofilin antibody (AB93323)

Immunofluorescent analysis of Mitofilin using anti-Mitofilin polyclonal antibody (ab93323) shows staining in p19 Cells.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IMMT.

Q16891

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.05% Sodium azide Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Mitofilin also known as mitofilin or MIM is a protein with a mass of approximately 88 kDa. This protein is integral to the inner mitochondrial membrane. Mitofilin is found in various tissues with high expression in the heart and skeletal muscle indicating its significant role in energy-demanding tissues. It is the central component of the mitochondrial inner membrane organizing system (MINOS) which plays a fundamental role in maintaining the mitochondrial architecture.
Biological function summary

Within the mitochondrial environment mitofilin contributes to maintaining cristae morphology which is essential for optimal mitochondrial respiration and energy production. As part of the MINOS complex mitofilin interacts with other proteins such as Mic60 and Mic10 stabilizing the structure of crista junctions. This process ensures efficient electron transport chain function ultimately supporting ATP synthesis. Without effective shaping of the cristae cellular energy metabolism deteriorates.

Pathways

Research has highlighted the importance of mitofilin in apoptosis and bioenergetics pathways. It interacts with proteins like OPA1 a dynamin-related GTPase important for mitochondrial fusion and energy metabolism. Additionally mitofilin influences the release of cytochrome c an important step in the initiation of apoptosis. Proper functioning of these pathways is critical for cellular balance and survival showing mitofilin’s broad impact on cellular processes.

Mitofilin has links to mitochondrial myopathies and cardiomyopathies. These disorders stem from impaired mitochondrial function significantly affecting muscle tissues and heart performance. Disruption in mitofilin expression or function can lead to compromised energy production contributing to these conditions. Furthermore mitofilin has associations with proteins like Drp1 involved in mitochondrial dynamics and this relationship can influence the progression and severity of mitochondrial-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed : 22114354, PubMed : 25781180, PubMed : 32567732, PubMed : 33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed : 22114354, PubMed : 25781180, PubMed : 32567732, PubMed : 33130824).
See full target information IMMT
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 9:136 PubMed37100799

2023

High glucose-induced STING activation inhibits diabetic wound healing through promoting M1 polarization of macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Kang Geng,Xiumei Ma,Zongzhe Jiang,Wei Huang,Junling Gu,Peng Wang,Lifang Luo,Youhua Xu,Yong Xu

Experimental neurology 288:167-175 PubMed27889468

2016

Mitochondrial cristae remodelling is associated with disrupted OPA1 oligomerisation in the Huntington's disease R6/2 fragment model.

Applications

Unspecified application

Species

Unspecified reactive species

Tanja Hering,Kerstin Kojer,Nathalie Birth,Jaqueline Hallitsch,Jan-Willem Taanman,Michael Orth

Oncology letters 12:3478-3484 PubMed27900024

2016

Acute effect of lactic acid on tumor-endothelial cell metabolic coupling in the tumor microenvironment.

Applications

WB

Species

Human

Guanqun Zhu,Degui Wang,Shenqian Li,Xuecheng Yang,Yanwei Cao,Yonghua Wang,Haitao Niu

International journal of clinical and experimental 8:12327-36 PubMed26550142

2015

The study of energy metabolism in bladder cancer cells in co-culture conditions using a microfluidic chip.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Dong Xu,Shi-Xiu Shao,Yan-Wei Cao,Xue-Cheng Yang,Hao-Qing Shi,You-Lin Wang,Sen-Yao Xue,Xin-Sheng Wang,Hai-Tao Niu
View all publications
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