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AB317172

Anti-MLK4 antibody [HL2234]

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Rabbit Recombinant Monoclonal MLK4 antibody. Suitable for ICC/IF, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MAP3K21.

View Alternative Names

KIAA1804, MLK4, MAP3K21, Mitogen-activated protein kinase kinase kinase 21, Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-MLK4 antibody [HL2234] (AB317172)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MLK4 antibody [HL2234] (AB317172)

ab317172 detects MLK4 protein at cytoplasm by immunofluorescent analysis. Sample : HeLa cells were fixed in ice-cold MeOH for 5 min. Green : MLK4 stained by ab317172 diluted at 1 : 200. Red : alpha Tubulin a cytoskeleton marker stained by alpha Tubulin antibody [GT114] diluted at 1 : 1000. Blue : Fluoroshield with DAPI.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

HL2234

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MAP3K21.

Q5TCX8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/200", "ICCIF-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MLK4 also known as Mixed Lineage Kinase 4 is a signaling protein involved in various cellular processes. It is a member of the MAP3K family and has a molecular weight of approximately 88 kDa. MLK4 is expressed in several tissues including the brain liver and kidney suggesting it plays roles in diverse physiological contexts. As a kinase it participates in phosphorylating specific substrates which impacts downstream signaling pathways.
Biological function summary

MLK4 influences cell proliferation differentiation and apoptosis through its kinase activity. It is part of signaling complexes that coordinate cellular responses to external stimuli linking surface receptors to the intracellular machinery. Through these roles MLK4 exerts important effects on cellular dynamics and maintenance of normal physiological balance.

Pathways

MLK4 integrates into the JNK and p38 MAPK signaling cascades which mediate responses to stress stimuli and regulate gene expression. MLK4 interacts with various other proteins including MLK3 to modulate these pathways effectively. Furthermore its role in these pathways positions MLK4 as an important player in ensuring cells react appropriately to potential damage or stress signals.

MLK4 has been associated with certain cancers and neurodegenerative diseases. Its involvement in cancer relates to its ability to influence cell growth and survival where MLK4 mutations or dysregulation might promote tumorigenesis. Moreover altered MLK4 signaling has links to Parkinson's disease particularly in conjunction with other kinases like LRRK2 suggesting its potential as a therapeutic target for modulating disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
See full target information MAP3K21
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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