AB38929

Anti-MMP1 antibody

Name: Anti-MMP1 antibody (ab38929) | Abcam
Brand: Abcam Limited
SKU: AB38929
Rating: 4 (6 reviews)

(6 Reviews)

(64 Publications)

Rabbit Polyclonal MMP1 antibody. Suitable for WB and reacts with Human samples. Cited in 64 publications. Immunogen corresponding to Synthetic Peptide within Human MMP1.

View Alternative Names

CLG, MMP1, Interstitial collagenase, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1

1 Images

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Western blot - Anti-MMP1 antibody (AB38929)

All lanes:

Western blot - Anti-MMP1 antibody (ab38929)

Lane 1:

Human MMP1

Lane 2:

Cell Media from human chondrosarcoma (no treatment)

Lane 3:

Cell Media from human chondrosarcoma (treated with TPA)

Predicted band size: 54 kDa

Observed band size: 53 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human MMP1. The exact immunogen used to generate this antibody is proprietary information.

P03956

Specificity

This antibody binds to MMP1, but does not cross react with the other MMP family members (MMP2, MMP3, MMP9).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000", "WB-species-notes": "<p>When used against the reduced protein this antibody identifies bands at 53 Kd and 51 Kd (the pro-form), as well as the initial active forms. Dilution optimised using Chromogenic detection.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP1 also known as collagenase-1 is an enzyme belonging to the matrix metalloproteinase (MMP) family. It is responsible for the degradation of type I II and III collagens making it an important player in collagen turnover. MMP1 has a molecular weight of approximately 54 kDa. This enzyme is expressed in various tissues including skin lung and reproductive organs primarily during tissue remodeling and repair. Scientists often use MMP1 ELISA kits and MMP1 inhibitors to study its expression and activity levels.

Biological function summary

MMP1 plays a significant role in the modulation of the extracellular matrix. It facilitates cellular processes by breaking down structural proteins and allowing for cell migration proliferation and differentiation. Although it acts independently MMP1 works in harmony with other MMP family members to maintain extracellular matrix homeostasis and is often linked to tissue remodeling complexes. This makes the MMP1 a valuable target for researchers interested in tissue repair and fibrosis.

Pathways

Studies show MMP1 involvement in critical processes such as the inflammatory response and wound healing. In the inflammatory pathway MMP1 expression is regulated by cytokines that respond to tissue injury. Within the wound healing pathway this enzyme interacts with proteins like transforming growth factor-beta (TGF-beta) to coordinate the repair process by remodeling extracellular matrix components. This illustrates the interconnected nature of MMP1 with significant regulatory proteins.

MMP1 has significant associations with osteoarthritis and cancer metastasis. MMP1 contributes to the breakdown of cartilage in osteoarthritis highlighting its role in disease progression and joint degradation. In the context of cancer elevated MMP1 expression correlates with the metastatic potential where it assists tumor invasion by degrading the surrounding matrix. MMP1's involvement with other MMPs including MMP2 and MMP9 highlights its importance in these pathological conditions making it a therapeutic target in related research.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed : 1645757, PubMed : 2153297, PubMed : 2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed : 16807369).

See full target information MMP1

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Publications (64)

Recent publications for all applications. Explore the full list and refine your search

ACS omega 10:36994-37003 PubMed40893218

2025

Potential Antiphotoaging Effect of Human Cathelicidin LL-37 Fragments and KR-12 Analogs on UVB-Induced HaCaT Cells and UVA-Induced HDF Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Menggeng Li,Jing Wang,Peng Shu,Xueqing Chen,Yizhen Yan,Jiangming Zhong,Nan Zhao,Ling Liang,Zhao Liu

Journal of clinical medicine 14: PubMed40094840

2025

Relationship Between Epidermal Matrix Metalloproteinase-1 and Dermal Collagen Reduction in Skin Subjected to Chronic Sun Exposure.

Applications

Unspecified application

Species

Unspecified reactive species

Ushio Hanai,Keigo Kawabata,Yotaro Tsunoda,Hitoshi Nemoto,Kotaro Imagawa,Ayumi Kusaka-Kikushima,Yoshito Takahashi,Hiroyuki Yoshida,Tadashi Akamatsu

Cells 13: PubMed39451222

2024

Decreased Circulating Gonadotropin-Releasing Hormone Associated with Keratoconus.

Applications

Unspecified application

Species

Unspecified reactive species

Paulina Escandon,Alexander J Choi,Steve Mabry,Sarah E Nicholas,Rebecca L Cunningham,Liam Redden,David A Murphy,Kamran M Riaz,Tina B McKay,Dimitrios Karamichos

Biomolecules & therapeutics 32:224-230 PubMed38173141

2024

The Anti-Diabetic Pinitol Improves Damaged Fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Ji-Yong Jung,Joong Hyun Shim,Su Hae Cho,Il-Hong Bae,Seung Ha Yang,Jinsick Kim,Hye Won Lim,Dong Wook Shin

Kidney360 4:1562-1579 PubMed37858297

2023

Molecular Phenotyping and Mechanisms of Myocardial Fibrosis in Advanced Chronic Kidney Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Gayatri Narayanan,Arvin Halim,Alvin Hu,Keith G Avin,Tzongshi Lu,Daniel Zehnder,Takashi Hato,Neal X Chen,Sharon M Moe,Kenneth Lim

Environmental toxicology 38:1678-1689 PubMed37087754

2023

NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Wu,Huijiang Zhang,Shengjie You,Zhaoyu Xu,Xiang Liu,Xuedong Chen,Weili Zhang,Junjie Ye,Peng Li,Xiaoqing Zhou

Antioxidants (Basel, Switzerland) 12: PubMed37107277

2023

The Cytoprotective Effects of Baicalein on HO-Induced ROS by Maintaining Mitochondrial Homeostasis and Cellular Tight Junction in HaCaT Keratinocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Gyeonghyeon Kim,Dong-Wook Han,Jong Hun Lee

eLife 12: PubMed36757365

2023

Correction: Dichotomous role of the human mitochondrial Na/Ca2/Li exchanger NCLX in colorectal cancer growth and metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Trayambak Pathak,Maxime Gueguinou,Vonn Walter,Celine Delierneux,Martin T Johnson,Xuexin Zhang,Ping Xin,Ryan E Yoast,Scott M Emrich,Gregory S Yochum,Israel Sekler,Walter A Koltun,Donald L Gill,Nadine Hempel,Mohamed Trebak

Photodermatology, photoimmunology & photomedicine 39:332-342 PubMed36208217

2022

Skin type specific photobiological response to visible light is mediated by constitutional melanin.

Applications

Unspecified application

Species

Unspecified reactive species

Hester Gail Lim,Michelle L Kerns,Isabelle D Brown,Sewon Kang,Anna L Chien

Scientific reports 12:13639 PubMed35948625

2022

Comprehensive bioinformatic analysis of MMP1 in hepatocellular carcinoma and establishment of relevant prognostic model.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Dai,Joseph Mugaanyi,Xingchen Cai,Mingjun Dong,Caide Lu,Changjiang Lu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MMP1 antibody

Western blot - Anti-MMP1 antibody (AB38929)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (64)

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