Rabbit Polyclonal MMP1 antibody. Suitable for WB and reacts with Human samples. Cited in 56 publications. Immunogen corresponding to Synthetic Peptide within Human MMP1.
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- Antioxidants (Basel, Switzerland) 12:2023The Cytoprotective Effects of Baicalein on HO-Induced ROS by Maintaining Mitochondrial Homeostasis and Cellular Tight Junction in HaCaT Keratinocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGyeonghyeon Kim,Dong-Wook Han,Jong Hun LeePubMed 37107277
- eLife 12:2023Correction: Dichotomous role of the human mitochondrial Na/Ca2/Li exchanger NCLX in colorectal cancer growth and metastasis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTrayambak Pathak,Maxime Gueguinou,Vonn Walter,Celine Delierneux,Martin T Johnson,Xuexin Zhang,Ping Xin,Ryan E Yoast,Scott M Emrich,Gregory S Yochum,Israel Sekler,Walter A Koltun,Donald L Gill,Nadine Hempel,Mohamed TrebakPubMed 36757365
- Photodermatology, photoimmunology & photomedicine 39:332-3422022Skin type specific photobiological response to visible light is mediated by constitutional melanin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHester Gail Lim,Michelle L Kerns,Isabelle D Brown,Sewon Kang,Anna L ChienPubMed 36208217
- Scientific reports 12:136392022Comprehensive bioinformatic analysis of MMP1 in hepatocellular carcinoma and establishment of relevant prognostic model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLei Dai,Joseph Mugaanyi,Xingchen Cai,Mingjun Dong,Caide Lu,Changjiang LuPubMed 35948625
- Breast cancer (Dove Medical Press) 14:187-1982022miR-623 Targets Metalloproteinase-1 and Attenuates Extravasation of Brain Metastatic Triple-Negative Breast Cancer Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDua Hammash,Mona Mahfood,Ghalia Khoder,Munazza Ahmed,Abdelaziz Tlili,Rifat Hamoudi,Rania HaratiPubMed 35936987
- Nature communications 12:52562021Disrupting biological sensors of force promotes tissue regeneration in large organisms.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKellen Chen,Sun Hyung Kwon,Dominic Henn,Britta A Kuehlmann,Ruth Tevlin,Clark A Bonham,Michelle Griffin,Artem A Trotsyuk,Mimi R Borrelli,Chikage Noishiki,Jagannath Padmanabhan,Janos A Barrera,Zeshaan N Maan,Teruyuki Dohi,Chyna J Mays,Autumn H Greco,Dharshan Sivaraj,John Q Lin,Tobias Fehlmann,Alana M Mermin-Bunnell,Smiti Mittal,Michael S Hu,Alsu I Zamaleeva,Andreas Keller,Jayakumar Rajadas,Michael T Longaker,Michael Januszyk,Geoffrey C GurtnerPubMed 34489407
- Experimental biology and medicine (Maywood, N.J.) 246:2454-24622021Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDan Gong,Hui Zhu,Lei Zeng,Ronghuan Hu,Jiali Hu,Jianwu DingPubMed 34293937
- American journal of cancer research 11:2537-25672021Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQiushi Lin,Xuesong Chen,Fanzheng Meng,Kosuke Ogawa,Min Li,Ruipeng Song,Shugeng Zhang,Ziran Zhang,Xianglu Kong,Qinggang Xu,Fuliang He,Dan Liu,Xuewei Bai,Bei Sun,Mien-Chie Hung,Lianxin Liu,Jack R Wands,Xiaoqun DongPubMed 34249415
- Toxicological sciences : an official journal of the Society of Toxicology 181:215-2282021Organophosphate Flame Retardants, Highly Fluorinated Chemicals, and Biomarkers of Placental Development and Disease During Mid-Gestation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJulia R Varshavsky,Joshua F Robinson,Yan Zhou,Kenisha A Puckett,Elaine Kwan,Sirirak Buarpung,Rayyan Aburajab,Stephanie L Gaw,Saunak Sen,Songmei Gao,Sabrina Crispo Smith,June-Soo Park,Igor Zakharevich,Roy R Gerona,Susan J Fisher,Tracey J WoodruffPubMed 33677611
- International journal of medical sciences 18:792-8002021Integrated bioinformatics analysis for differentially expressed genes and signaling pathways identification in gastric cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChenChen Yang et. al.PubMed 33437215
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human MMP1. The exact immunogen used to generate this antibody is proprietary information. Database link P03956
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/5000 | Notes When used against the reduced protein this antibody identifies bands at 53 Kd and 51 Kd (the pro-form), as well as the initial active forms. Dilution optimised using Chromogenic detection. |
Associated Products
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Target data
Function
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369).
Alternative names
CLG, MMP1, Interstitial collagenase, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1
Recommended products
Rabbit Polyclonal MMP1 antibody. Suitable for WB and reacts with Human samples. Cited in 56 publications. Immunogen corresponding to Synthetic Peptide within Human MMP1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human MMP1. The exact immunogen used to generate this antibody is proprietary information. Database link P03956
- Purification technique
- Affinity purification Immunogen
- Specificity
This antibody binds to MMP1, but does not cross react with the other MMP family members (MMP2, MMP3, MMP9).
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MMP1 also known as collagenase-1 is an enzyme belonging to the matrix metalloproteinase (MMP) family. It is responsible for the degradation of type I II and III collagens making it an important player in collagen turnover. MMP1 has a molecular weight of approximately 54 kDa. This enzyme is expressed in various tissues including skin lung and reproductive organs primarily during tissue remodeling and repair. Scientists often use MMP1 ELISA kits and MMP1 inhibitors to study its expression and activity levels.
- Biological function summary
MMP1 plays a significant role in the modulation of the extracellular matrix. It facilitates cellular processes by breaking down structural proteins and allowing for cell migration proliferation and differentiation. Although it acts independently MMP1 works in harmony with other MMP family members to maintain extracellular matrix homeostasis and is often linked to tissue remodeling complexes. This makes the MMP1 a valuable target for researchers interested in tissue repair and fibrosis.
- Pathways
Studies show MMP1 involvement in critical processes such as the inflammatory response and wound healing. In the inflammatory pathway MMP1 expression is regulated by cytokines that respond to tissue injury. Within the wound healing pathway this enzyme interacts with proteins like transforming growth factor-beta (TGF-beta) to coordinate the repair process by remodeling extracellular matrix components. This illustrates the interconnected nature of MMP1 with significant regulatory proteins.
- Associated diseases and disorders
MMP1 has significant associations with osteoarthritis and cancer metastasis. MMP1 contributes to the breakdown of cartilage in osteoarthritis highlighting its role in disease progression and joint degradation. In the context of cancer elevated MMP1 expression correlates with the metastatic potential where it assists tumor invasion by degrading the surrounding matrix. MMP1's involvement with other MMPs including MMP2 and MMP9 highlights its importance in these pathological conditions making it a therapeutic target in related research.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-MMP1 antibody (ab38929)
All lanes: Western blot - Anti-MMP1 antibody (ab38929)
Lane 1: Human MMP1.
Lane 2: Cell Media from human chondrosarcoma (no treatment).
Lane 3: Cell Media from human chondrosarcoma (treated with TPA).
Predicted band size: 54 kDa
Observed band size: 53 kDa
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