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AB261733

Anti-MMP10 antibody

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(7 Publications)

Rabbit Polyclonal MMP10 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MMP10.

View Alternative Names

STMY2, MMP10, Stromelysin-2, SL-2, Matrix metalloproteinase-10, Transin-2, MMP-10

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP10 antibody (AB261733)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP10 antibody (AB261733)

Paraffin-embedded human kidney tissue labeling MMP10 using ab261733 at a 1/50 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-MMP10 antibody (AB261733)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MMP10 antibody (AB261733)

Immunofluorescent analysis of HepG2 (Human liver hepatocellular carcinoma cell line) cells labeling MMP10 using ab261733 at a 1/100 dilution followed by an Alexa-Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-MMP10 antibody (AB261733)
  • WB

Supplier Data

Western blot - Anti-MMP10 antibody (AB261733)

All lanes:

Western blot - Anti-MMP10 antibody (ab261733) at 2 µg/mL

All lanes:

Mouse kidney tissue lysate

Secondary

All lanes:

Goat anti-Rabbit IgG polyclonal at 1/10000 dilution

Predicted band size: 54 kDa

false

Western blot - Anti-MMP10 antibody (AB261733)
  • WB

Supplier Data

Western blot - Anti-MMP10 antibody (AB261733)

All lanes:

Western blot - Anti-MMP10 antibody (ab261733) at 4.5 µg/mL

All lanes:

Mouse heart lysate

Secondary

All lanes:

Goat anti-Rabbit IgG polyclonal at 1/50000 dilution

Predicted band size: 54 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MMP10.

P09238

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity is greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP10 also known as stromelysin-2 is a member of the matrix metalloproteinase (MMP) family. This protein is involved in the degradation of components of the extracellular matrix. MMP10 weighs around 54 kDa in its native form. It gets expressed in various tissues including the skin lung and reproductive organs and plays a part in processes like tissue remodeling and repair. Unlike other MMPs MMP10 does not usually cleave collagen but breaks down proteins like elastin and gelatin. The Luminex MMP assay is a method used to study this protein's expression and regulation.
Biological function summary

MMP10 impacts the restructuring and turnover of the extracellular matrix in both normal and disease conditions. It does not work alone; it operates synergistically with other MMPs in a complex matrix framework. Within tissues MMP10 modifies the integrity of the extracellular environment affecting cell behaviors such as migration and invasion. It steps in during processes like wound healing and inflammation exemplifying its contribution to cellular repair mechanisms and their regulation.

Pathways

The activity of MMP10 intersects with the MAPK and TGF-beta signaling pathways. MMP10 facilitates these pathways by digesting extracellular matrix barriers which then influences cellular responses. MMP10's function is also linked with other metalloproteinases like MMP1 and MMP3 in the pathways. Its regulation and activation play an important role in maintaining cellular homeostasis and responding to environmental cues.

MMP10 is associated with conditions such as cancer and arthritis. In cancer its role in promoting extracellular matrix breakdown facilitates tumor cell invasion and metastasis. In arthritis MMP10 contributes to joint tissue destruction perpetuating the inflammatory cycle. This protein frequently collaborates with MMP13 in these diseases reflecting its significant part in disease progression and pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
See full target information MMP10
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 10: PubMed40857403

2025

The spleen tyrosine kinase inhibitor entospletinib resolves inflammation to promote repair following acute kidney injury.

Applications

Unspecified application

Species

Unspecified reactive species

Esteban E Elias,Arthur Lau,Sisay Getie Belay,Afshin Derakhshani,Graciela Andonegui,Craig N Jenne,Antoine Dufour,Nathan A Bracey,Justin Chun,Daniel A Muruve

Antioxidants (Basel, Switzerland) 13: PubMed39456453

2024

NADPH Oxidase 5 (NOX5) Upregulates MMP-10 Production and Cell Migration in Human Endothelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Javier Marqués,Elena Ainzúa,Josune Orbe,María Martínez-Azcona,José Martínez-González,Guillermo Zalba

Frontiers in immunology 15:1366319 PubMed38799464

2024

MiR-146a alleviates inflammatory bowel disease in mice through systematic regulation of multiple genetic networks.

Applications

Unspecified application

Species

Unspecified reactive species

Fengting Zhu,Taotan Yang,Mengmeng Ning,Yang Liu,Wei Xia,Yan Fu,Ting Wen,Mei Zheng,Ruilong Xia,Ran Qian,Yang Li,Minxuan Sun,Jianping Liu,Li Tian,Qian Zhou,Xin Yu,Changgeng Peng

Cell death & disease 14:215 PubMed36973255

2023

HOXB3 drives WNT-activation associated progression in castration-resistant prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Shimiao Zhu,Zhao Yang,Zheng Zhang,Hongli Zhang,Songyang Li,Tao Wu,Xuanrong Chen,Jianing Guo,Aixiang Wang,Hao Tian,Jianpeng Yu,Changwen Zhang,Lei Su,Zhiqun Shang,Changyi Quan,Yuanjie Niu

Bioengineered 13:1198-1208 PubMed35000533

2022

Taxifolin improves inflammatory injury of human bronchial epithelial cells by inhibiting matrix metalloproteinase (MMP) 10 via Wnt/β-catenin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Youhua Chen,Yan Mei,Lu Yang,Weibin Li,Yu Zhou,Surong He,Jie Liang

mBio :e0314421 PubMed35089096

2022

Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma and .

Applications

Unspecified application

Species

Unspecified reactive species

Máté Vadovics,Jemima Ho,Nóra Igaz,Róbert Alföldi,Dávid Rakk,Éva Veres,Balázs Szücs,Márton Horváth,Renáta Tóth,Attila Szücs,Andrea Csibi,Péter Horváth,László Tiszlavicz,Csaba Vágvölgyi,Joshua D Nosanchuk,András Szekeres,Mónika Kiricsi,Rhonda Henley-Smith,David L Moyes,Selvam Thavaraj,Rhys Brown,László G Puskás,Julian R Naglik,Attila Gácser

Clinical and translational medicine 11:e613 PubMed34709743

2021

A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Wang,Jiahui Zhou,Chuan Zhang,Ranran Chen,Qingyang Sun,Peng Yang,Chaofan Peng,Yuqian Tan,Chi Jin,Tuo Wang,Jiangzhou Ji,Yueming Sun
View all publications
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