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BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
Learn about all product ranges with our product overviews.
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Rabbit Polyclonal MMP11 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MMP11 conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride
Liquid
Polyclonal
WB | ICC/IF | IHC-P | |
---|---|---|---|
Human | Tested | Tested | Tested |
Mouse | Predicted | Predicted | Predicted |
Rat | Predicted | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
May play an important role in the progression of epithelial malignancies.
Stromelysin-3, SL-3, ST3, Matrix metalloproteinase-11, MMP-11, MMP11, STMY3
Rabbit Polyclonal MMP11 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MMP11 conjugated to Keyhole Limpet Haemocyanin.
Stromelysin-3, SL-3, ST3, Matrix metalloproteinase-11, MMP-11, MMP11, STMY3
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride
Liquid
Polyclonal
Affinity purification Protein A
Blue Ice
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
The modulation of the extracellular matrix by MMP11 helps in regulating tissue architecture and cellular interactions. Unlike other MMPs MMP11 does not participate in large protein complexes but acts mainly at the cellular boundaries. It helps facilitate tumor cell invasion by altering the local matrix environment and can modify growth factor activity aiding in cell proliferation and migration.
MMP11 also known as stromelysin-3 is a matrix metalloproteinase with a mass of approximately 54 kDa. It participates in the breakdown of extracellular matrix components particularly during tissue remodeling and wound healing. MMP11 demonstrates unique mechanical behavior when compared to other MMPs as it prefers cleaving non-matrix substrates like alpha1-proteinase inhibitor. Expression levels of MMP11 vary but are commonly found in tissues undergoing active remodeling including the placenta and stroma of breast tumors.
MMP11 is deeply integrated into the tissue remodeling and invasion pathways. It associates with the serine protease pathway known for its role in regulating the extracellular environment. MMP11 is linked to proteins like TIMP1 which is a natural inhibitor and works together in maintaining the balance of extracellular matrix deposition and degradation.
Overexpression of MMP11 is frequently observed in various cancers such as breast and gastric cancer. Its contribution to tumor progression makes it a significant focus in cancer research. MMP11's interaction with other factors like insulin-like growth factor binding proteins influences cellular processes that compromise tissue integrity further linking it to cancer metastasis and progression. This relationship highlights its potential as a therapeutic target in oncology.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
ab119284, at 10 µg/ml, staining MMP11 in Formalin-fixed, Paraffin-embedded Human placenta tissue by Immunohistochemistry.
ab119284, at 10 µg/ml, staining MMP11 in Formalin-fixed, Paraffin-embedded Human spleen tissue by Immunohistochemistry.
All lanes: Western blot - Anti-MMP11 antibody (AB119284) at 1/500 dilution
All lanes: A549 cell lysate
Predicted band size: 55 kDa
ab119284, at 1/100, staining MMP11 in A549 cells by Immunofluorescence. The image on the right shows cells treated with synthesised peptide.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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