AB119284

Anti-MMP11 antibody

Name: Anti-MMP11 antibody (ab119284) | Abcam
Brand: Abcam Limited
SKU: AB119284
Price: 620 USD
Availability: InStock

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(9 Publications)

Rabbit Polyclonal MMP11 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human MMP11 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

STMY3, MMP11, Stromelysin-3, SL-3, ST3, Matrix metalloproteinase-11, MMP-11

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP11 antibody (AB119284)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP11 antibody (AB119284)

ab119284, at 10 µg/ml, staining MMP11 in Formalin-fixed, Paraffin-embedded Human placenta tissue by Immunohistochemistry.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP11 antibody (AB119284)

ab119284, at 10 µg/ml, staining MMP11 in Formalin-fixed, Paraffin-embedded Human spleen tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-MMP11 antibody (AB119284)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MMP11 antibody (AB119284)

ab119284, at 1/100, staining MMP11 in A549 cells by Immunofluorescence. The image on the right shows cells treated with synthesised peptide.

Unknown

Western blot - Anti-MMP11 antibody (AB119284)

All lanes:

Western blot - Anti-MMP11 antibody (ab119284) at 1/500 dilution

Lane 1:

A549 cell lysate

Lane 2:

A549 cell lysate with synthesized peptide

Predicted band size: 55 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human MMP11 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P24347

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP11 also known as stromelysin-3 is a matrix metalloproteinase with a mass of approximately 54 kDa. It participates in the breakdown of extracellular matrix components particularly during tissue remodeling and wound healing. MMP11 demonstrates unique mechanical behavior when compared to other MMPs as it prefers cleaving non-matrix substrates like alpha1-proteinase inhibitor. Expression levels of MMP11 vary but are commonly found in tissues undergoing active remodeling including the placenta and stroma of breast tumors.

Biological function summary

The modulation of the extracellular matrix by MMP11 helps in regulating tissue architecture and cellular interactions. Unlike other MMPs MMP11 does not participate in large protein complexes but acts mainly at the cellular boundaries. It helps facilitate tumor cell invasion by altering the local matrix environment and can modify growth factor activity aiding in cell proliferation and migration.

Pathways

MMP11 is deeply integrated into the tissue remodeling and invasion pathways. It associates with the serine protease pathway known for its role in regulating the extracellular environment. MMP11 is linked to proteins like TIMP1 which is a natural inhibitor and works together in maintaining the balance of extracellular matrix deposition and degradation.

Overexpression of MMP11 is frequently observed in various cancers such as breast and gastric cancer. Its contribution to tumor progression makes it a significant focus in cancer research. MMP11's interaction with other factors like insulin-like growth factor binding proteins influences cellular processes that compromise tissue integrity further linking it to cancer metastasis and progression. This relationship highlights its potential as a therapeutic target in oncology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May play an important role in the progression of epithelial malignancies.

See full target information MMP11

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastrointestinal oncology 17:110527 PubMed40977645

2025

Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11.

Applications

Unspecified application

Species

Unspecified reactive species

Hong-Peng Tian,Tian-Hao Wu,Guang-Jun Zhang,Sheng-Jie Li

Communications biology 8:696 PubMed40319103

2025

Single-cell RNA sequencing reveals a fibroblast gene signature that promotes T-cell infiltration in muscle-invasive bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zige Liu,Xingning Mao,Yuli Xie,Yunkun Yan,Xiang Wang,Junhao Mi,Hao Yuan,Jiange Zhang,Caisheng Huang,Jianxin Chen,Mujia Jili,Shengzhu Huang,Qingyun Zhang,Fubo Wang,Zengnan Mo,Rirong Yang

Nature communications 15:1200 PubMed38331898

2024

UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Yin Li,Manling Jiang,Ling Aye,Li Luo,Yong Zhang,Fengkai Xu,Yongqi Wei,Dan Peng,Xiang He,Jie Gu,Xiaofang Yu,Guoping Li,Di Ge,Chunlai Lu

BMC biology 20:276 PubMed36482461

2022

An IGF1-expressing endometrial stromal cell population is associated with human decidualization.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Wei Shi,Zhen-Zhen Lai,Hui-Li Yang,Wen-Jie Zhou,Xiao-Ya Zhao,Feng Xie,Song-Ping Liu,Wei-Dong Chen,Tao Zhang,Jiang-Feng Ye,Xiang-Yu Zhou,Ming-Qing Li

Frontiers in pharmacology 13:944376 PubMed36313295

2022

Preclinical reserpine models recapitulating motor and non-motor features of Parkinson's disease: Roles of epigenetic upregulation of alpha-synuclein and autophagy impairment.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Li,Qiao Yin,Bing Wang,Tingting Shen,Weifeng Luo,Tong Liu

Bioengineered 13:9211-9231 PubMed35436411

2022

Lamin B1 is a potential therapeutic target and prognostic biomarker for hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yongyu Yang,Lei Gao,Junzhang Chen,Wang Xiao,Ruoqi Liu,Heping Kan

Cancer cell international 21:202 PubMed33836753

2021

LINC00221 silencing prevents the progression of hepatocellular carcinoma through let-7a-5p-targeted inhibition of MMP11.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Yang,Hailong Si,Meng Ma,Yu Fang,Yina Jiang,Jintao Wang,Cheng Zhang,Haijuan Xiao

Oncology reports 45: PubMed33649832

2021

MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Zhuang,Xiang Li,Peng Zhan,Guoliang Pi,Gu Wen

Anticancer research 39:5963-5971 PubMed31704821

2019

Identification of Matrix Metalloproteinase 11 as a Prognostic Biomarker in Pancreatic Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jungwhoi Lee,Jungsul Lee,Jae Hoon Kim

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MMP11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP11 antibody (AB119284)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP11 antibody (AB119284)

Immunocytochemistry/ Immunofluorescence - Anti-MMP11 antibody (AB119284)

Western blot - Anti-MMP11 antibody (AB119284)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Secondary Antibodies

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Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise