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AB236510

Anti-MMP11 antibody [OTI3E10]

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(1 Publication)

Mouse Monoclonal MMP11 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMP11 aa 200 to C-terminus.

View Alternative Names

STMY3, MMP11, Stromelysin-3, SL-3, ST3, Matrix metalloproteinase-11, MMP-11

2 Images
Western blot - Anti-MMP11 antibody [OTI3E10] (AB236510)
  • WB

Supplier Data

Western blot - Anti-MMP11 antibody [OTI3E10] (AB236510)

All lanes:

Western blot - Anti-MMP11 antibody [OTI3E10] (ab236510) at 1/500 dilution

Lane 1:

MDA-MB-231 (human breast adenocarcinoma cell line) whole cell lysate at 35 µg

Lane 2:

T-47D (human ductal breast epithelial tumor cell line) whole cell lysate at 35 µg

Predicted band size: 55 kDa

false

Western blot - Anti-MMP11 antibody [OTI3E10] (AB236510)
  • WB

Supplier Data

Western blot - Anti-MMP11 antibody [OTI3E10] (AB236510)

All lanes:

Western blot - Anti-MMP11 antibody [OTI3E10] (ab236510) at 1/500 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) transfected with pCMV6-ENTRY control at 5 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) transfected with pCMV6-ENTRY MMP11 at 5 µg

Predicted band size: 55 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI3E10

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human MMP11 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P24347

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from cell culture supernatant.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP11 also known as stromelysin-3 is a matrix metalloproteinase with a mass of approximately 54 kDa. It participates in the breakdown of extracellular matrix components particularly during tissue remodeling and wound healing. MMP11 demonstrates unique mechanical behavior when compared to other MMPs as it prefers cleaving non-matrix substrates like alpha1-proteinase inhibitor. Expression levels of MMP11 vary but are commonly found in tissues undergoing active remodeling including the placenta and stroma of breast tumors.
Biological function summary

The modulation of the extracellular matrix by MMP11 helps in regulating tissue architecture and cellular interactions. Unlike other MMPs MMP11 does not participate in large protein complexes but acts mainly at the cellular boundaries. It helps facilitate tumor cell invasion by altering the local matrix environment and can modify growth factor activity aiding in cell proliferation and migration.

Pathways

MMP11 is deeply integrated into the tissue remodeling and invasion pathways. It associates with the serine protease pathway known for its role in regulating the extracellular environment. MMP11 is linked to proteins like TIMP1 which is a natural inhibitor and works together in maintaining the balance of extracellular matrix deposition and degradation.

Overexpression of MMP11 is frequently observed in various cancers such as breast and gastric cancer. Its contribution to tumor progression makes it a significant focus in cancer research. MMP11's interaction with other factors like insulin-like growth factor binding proteins influences cellular processes that compromise tissue integrity further linking it to cancer metastasis and progression. This relationship highlights its potential as a therapeutic target in oncology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play an important role in the progression of epithelial malignancies.
See full target information MMP11
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 12: PubMed37010266

2023

Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Li,Xinqi Lou,Yingjie Zha,Yinyin Qin,Jun Zha,Lei Hong,Zhanli Xie,Shudi Yang,Chen Wang,Jianzhong An,Zhenhao Zhang,Shigang Qiao
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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