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AB154496

Anti-MMP19 antibody

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(1 Publication)

Rabbit Polyclonal MMP19 antibody. Suitable for WB, IHC-P and reacts with Transfected cell line, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMP19 aa 200-500.

View Alternative Names

MMP18, RASI, MMP19, Matrix metalloproteinase-19, MMP-19, Matrix metalloproteinase RASI, Matrix metalloproteinase-18, MMP-18

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP19 antibody (AB154496)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP19 antibody (AB154496)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human hepatoma tissue, labeling MMP19 using ab154496 at a 1/500 dilution.

Western blot - Anti-MMP19 antibody (AB154496)
  • WB

Supplier Data

Western blot - Anti-MMP19 antibody (AB154496)

All lanes:

Western blot - Anti-MMP19 antibody (ab154496) at 1/1000 dilution

Lane 1:

Non-transfected (–) 293T whole cell extracts at 30 µg

Lane 2:

Transfected (+) 293T whole cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MMP19 aa 200-500. The exact immunogen used to generate this antibody is proprietary information.

Q99542

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Transfected cell line": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP19 also known as Matrix Metalloproteinase 19 is an enzyme that plays a role in the breakdown of extracellular matrix components. The protein has a molecular weight of approximately 54 kDa. MMP19 is expressed in various tissues including the skin lung and cartilage. It participates in the remodeling of the extracellular matrix which is significant for processes such as tissue repair and embryonic development.
Biological function summary

MMP19 contributes to cellular processes by modulating the extracellular environment and interacting with other matrix proteins. It does not usually appear as a part of large complexes but may influence the behavior of cell migration proliferation and differentiation. Its action helps in regulating cellular responses to their environment which emphasizes its involvement in maintaining tissue homeostasis.

Pathways

MMP19 is associated with the extracellular matrix degradation pathway which is essential for tissue remodeling. It also interacts with signaling molecules in the MAPK pathway that integrate external signals into various cellular responses. Through these pathways MMP19 relates to other matrix metalloproteinases such as MMP2 and MMP9 contributing to coordinated extracellular matrix turnover.

Involvement of MMP19 is significant in cancer progression and rheumatoid arthritis. In cancer abnormal expression of MMP19 can lead to increased invasion and metastasis by degrading the extracellular matrix barriers. In rheumatoid arthritis MMP19 contributes to the breakdown of joint cartilage exacerbating the disease. MMP19's relationship with proteins like tissue inhibitors of metalloproteinases (TIMPs) further influences these disease processes by balancing its proteolytic activity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
See full target information MMP19
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2408529 PubMed39716999

2024

MLLT3 Regulates Melanoma Stemness and Progression by Inhibiting HMGB1 Nuclear Entry and MAGEA1 MC Modification.

Applications

Unspecified application

Species

Unspecified reactive species

Yaling Li,Hong Liu,Jingyi Li,Chang Fu,Bin Jiang,Bancheng Chen,Yanfen Zou,Bo Yu,Bing Song
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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