AB216633

Anti-MMP19 antibody

Name: Anti-MMP19 antibody (ab216633) | Abcam
Brand: Abcam Limited
SKU: AB216633
Price: 525 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal MMP19 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MMP19 aa 250-350 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

MMP18, RASI, MMP19, Matrix metalloproteinase-19, MMP-19, Matrix metalloproteinase RASI, Matrix metalloproteinase-18, MMP-18

1 Images

Supplier Data

Western blot - Anti-MMP19 antibody (AB216633)

All lanes:

Western blot - Anti-MMP19 antibody (ab216633) at 1/300 dilution

All lanes:

MCF7 cell lysate

Secondary

All lanes:

HRP-conjugated antibody at 1/500 dilution

Predicted band size: 57 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human MMP19 aa 250-350 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q99542

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP19 also known as Matrix Metalloproteinase 19 is an enzyme that plays a role in the breakdown of extracellular matrix components. The protein has a molecular weight of approximately 54 kDa. MMP19 is expressed in various tissues including the skin lung and cartilage. It participates in the remodeling of the extracellular matrix which is significant for processes such as tissue repair and embryonic development.

Biological function summary

MMP19 contributes to cellular processes by modulating the extracellular environment and interacting with other matrix proteins. It does not usually appear as a part of large complexes but may influence the behavior of cell migration proliferation and differentiation. Its action helps in regulating cellular responses to their environment which emphasizes its involvement in maintaining tissue homeostasis.

Pathways

MMP19 is associated with the extracellular matrix degradation pathway which is essential for tissue remodeling. It also interacts with signaling molecules in the MAPK pathway that integrate external signals into various cellular responses. Through these pathways MMP19 relates to other matrix metalloproteinases such as MMP2 and MMP9 contributing to coordinated extracellular matrix turnover.

Involvement of MMP19 is significant in cancer progression and rheumatoid arthritis. In cancer abnormal expression of MMP19 can lead to increased invasion and metastasis by degrading the extracellular matrix barriers. In rheumatoid arthritis MMP19 contributes to the breakdown of joint cartilage exacerbating the disease. MMP19's relationship with proteins like tissue inhibitors of metalloproteinases (TIMPs) further influences these disease processes by balancing its proteolytic activity.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.

See full target information MMP19

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 21:817 PubMed37974228

2023

HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell proliferation and metastasis via PI3K/AKT signaling pathway in human anaplastic thyroid carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Zhong,Fan Yu,Ling Yang,Yu Wang,Lin Liu,Chengyou Jia,Haidong Cai,Jianshe Yang,Shiyang Sheng,Zhongwei Lv,Li Weng,Bo Wu,Xiaoping Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-MMP19 antibody

Western blot - Anti-MMP19 antibody (AB216633)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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