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AB155416

Anti-MMP23 antibody

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(1 Publication)

Rabbit Polyclonal MMP23 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMP23B aa 50 to C-terminus.

View Alternative Names

MMP21, MMP22, MMP23B, Matrix metalloproteinase-23, MMP-23, Femalysin, MIFR-1, Matrix metalloproteinase-21, Matrix metalloproteinase-22, MMP-21, MMP-22

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP23 antibody (AB155416)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP23 antibody (AB155416)

Immunohistochemical analysis of paraffin embedded Cal27 xenograft, labeling MMP23 with ab155416 at 1/500.

Western blot - Anti-MMP23 antibody (AB155416)
  • WB

Unknown

Western blot - Anti-MMP23 antibody (AB155416)

10% SDS PAGE

All lanes:

Western blot - Anti-MMP23 antibody (ab155416) at 1/5000 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 43 kDa,44 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human MMP23B aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O75900

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10mM citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0).</p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein MMP23 also known as matrix metalloproteinase-23 plays a role in tissue remodeling and cellular processes. MMP23 is unique due to its membrane-type structure distinguishing it from other MMP family members. The protein weighs approximately 44 kDa. MMP23 is mainly found in a variety of tissues including the testis ovary and placenta but its expression is notably less widespread compared to other metalloproteinases.
Biological function summary

Matrix metalloproteinase-23 contributes to modulating extracellular matrix degradation. Unlike some MMPs MMP23 is part of a transmembrane complex impacting localized tissue environments. It influences cellular growth and communication through its regulatory effects on the extracellular space. Such interactions play a part in processes like cell migration and signal transduction important for normal physiological and developmental activities.

Pathways

MMP23 participates in specific biochemical pathways important for tissue repair and immune response. One significant pathway is the extracellular matrix (ECM) remodeling pathway where MMP23 interacts with other metalloproteinases such as MMP2. Additionally MMP23's activity affects signaling pathways by altering the ECM components which can influence cellular behaviors linked to proliferation and apoptosis.

Matrix metalloproteinase-23 implicates its role in certain pathologies including cancer and inflammatory diseases. Its ability to modify the extracellular matrix associates it with tumor invasion and metastasis particularly through interactions with proteins like TIMP (tissue inhibitors of metalloproteinases). Inflammatory conditions also show altered MMP23 activity indicating its potential involvement in chronic inflammation pathophysiology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).
See full target information MMP23B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Carcinogenesis 39:1254-1263 PubMed30052775

2018

MMP23B expression and protein levels in blood and urine are associated with bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Alessandra Allione,Barbara Pardini,Clara Viberti,Giuliana Giribaldi,Stefano Turini,Cornelia Di Gaetano,Simonetta Guarrera,Francesca Cordero,Marco Oderda,Marco Allasia,Paolo Gontero,Carlotta Sacerdote,Paolo Vineis,Giuseppe Matullo
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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