Anti-MMP23 antibody [EPR7769]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The protein MMP23 also known as matrix metalloproteinase-23 plays a role in tissue remodeling and cellular processes. MMP23 is unique due to its membrane-type structure distinguishing it from other MMP family members. The protein weighs approximately 44 kDa. MMP23 is mainly found in a variety of tissues including the testis ovary and placenta but its expression is notably less widespread compared to other metalloproteinases.

Biological function summary

Matrix metalloproteinase-23 contributes to modulating extracellular matrix degradation. Unlike some MMPs MMP23 is part of a transmembrane complex impacting localized tissue environments. It influences cellular growth and communication through its regulatory effects on the extracellular space. Such interactions play a part in processes like cell migration and signal transduction important for normal physiological and developmental activities.

Pathways

MMP23 participates in specific biochemical pathways important for tissue repair and immune response. One significant pathway is the extracellular matrix (ECM) remodeling pathway where MMP23 interacts with other metalloproteinases such as MMP2. Additionally MMP23's activity affects signaling pathways by altering the ECM components which can influence cellular behaviors linked to proliferation and apoptosis.

Associated diseases and disorders

Matrix metalloproteinase-23 implicates its role in certain pathologies including cancer and inflammatory diseases. Its ability to modify the extracellular matrix associates it with tumor invasion and metastasis particularly through interactions with proteins like TIMP (tissue inhibitors of metalloproteinases). Inflammatory conditions also show altered MMP23 activity indicating its potential involvement in chronic inflammation pathophysiology.