JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB233004

Anti-MMP24 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal MMP24 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMP24 aa 400 to C-terminus.

View Alternative Names

MT5MMP, MMP24, Matrix metalloproteinase-24, MMP-24, Membrane-type matrix metalloproteinase 5, Membrane-type-5 matrix metalloproteinase, MT-MMP 5, MTMMP5, MT5-MMP

11 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human skin cancer tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human liver tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human kidney tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human colorectal cancer tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP24 antibody (AB233004)

Formalin-fixed, paraffin-embedded human prostate tissue stained for MMP24 using ab233004 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-MMP24 antibody (AB233004)
  • WB

Supplier Data

Western blot - Anti-MMP24 antibody (AB233004)

All lanes:

Western blot - Anti-MMP24 antibody (ab233004) at 1.5 µg/mL

All lanes:

Rat kidney lysate

Predicted band size: 73 kDa

false

Western blot - Anti-MMP24 antibody (AB233004)
  • WB

Supplier Data

Western blot - Anti-MMP24 antibody (AB233004)

All lanes:

Western blot - Anti-MMP24 antibody (ab233004) at 2 µg/mL

All lanes:

Human liver lysate

Predicted band size: 73 kDa

false

Western blot - Anti-MMP24 antibody (AB233004)
  • WB

Supplier Data

Western blot - Anti-MMP24 antibody (AB233004)

All lanes:

Western blot - Anti-MMP24 antibody (ab233004) at 1.5 µg/mL

All lanes:

Rat pancreas lysate

Predicted band size: 73 kDa

false

Western blot - Anti-MMP24 antibody (AB233004)
  • WB

Supplier Data

Western blot - Anti-MMP24 antibody (AB233004)

All lanes:

Western blot - Anti-MMP24 antibody (ab233004) at 2 µg/mL

All lanes:

Recombinant human MMP24 protein

Predicted band size: 73 kDa

false

Western blot - Anti-MMP24 antibody (AB233004)
  • WB

Supplier Data

Western blot - Anti-MMP24 antibody (AB233004)

All lanes:

Western blot - Anti-MMP24 antibody (ab233004) at 1.5 µg/mL

All lanes:

Rat cerebrum lysate

Predicted band size: 73 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MMP24 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5R2

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Matrix Metalloproteinase 24 (MMP24) also known as MT5-MMP is an enzyme that plays a significant role in tissue remodeling and degradation of extracellular matrix components. This enzyme is membrane-anchored unlike its soluble counterparts and has a mass of approximately 72 kDa. MMP24 is expressed in neuronal tissues and shows high levels of activity in the brain and other parts of the central nervous system as well as in certain cancer cell types. MMP24 is implicated in several cellular processes due to its ability to cleave a variety of substrates.
Biological function summary

The enzyme is involved in the modulation of synaptic connections and neural plasticity. MMP24 functions as part of a complex which includes pro-protein convertases that activate the enzyme from its pro-form. These activities highlight its contribution to the regulation of neural networks. MMP24's interaction with neuronal substrates and their subsequent processing is vital for maintaining normal neural architecture and response to recovery processes after injury.

Pathways

MMP24 holds a significant role in the extracellular matrix (ECM) remodeling pathway and is linked to the integrin signaling pathway. These pathways are important for cell adhesion migration and survival. In the ECM remodeling pathway MMP24 interacts with other metalloproteinases such as MMP2 and MMP9 highlighting its contribution to the dynamic remodeling processes. In the integrin signaling pathway its activity affects cell-matrix interactions emphasizing its importance in cellular communication and structural organization within tissues.

Abnormalities in MMP24 expression and activity associate with neurodegenerative diseases like Alzheimer's and certain types of cancer including glioma. MMP24’s involvement in cancer emphasizes its role in promoting cancer cell invasion and metastasis due to its ECM degrading capability. It works in connection with other proteins like MMP14 which also plays a significant role in tumor progression and response to tumor microenvironmental changes. Understanding the regulation and activity of MMP24 could offer therapeutic insights into these pathological conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
See full target information MMP24
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:4124 PubMed40319020

2025

Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Jun-Kit Hu,Xiaoyu Tracy Cai,Jesse Simons,Jina Yun,Justin Elstrott,Heinrich Jasper
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB181118

Anti-MMP23 antibody [EPR7769]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-MMP23 antibody [EPR7769] (AB181118)

  • 0
  • 0
Primary Antibodies

AB109369

Anti-Biglycan antibody [EPR2959]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Biglycan antibody [EPR2959] (AB109369)

  • 1
  • 1
Primary Antibodies

AB318285

Anti-Heparan Sulfate Proteoglycan 2/Perlecan antibody [RM2059] - BSA and Azide free

BOND RX™ Validated|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Heparan Sulfate Proteoglycan 2/Perlecan antibody [RM2059] - BSA and Azide free (AB318285)

  • 0
  • 0
Primary Antibodies

AB119284

Anti-MMP11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP11 antibody (AB119284)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com