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AB317391

Anti-MMP26 Antibody [S01-7A4]

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Rabbit Monoclonal MMP26 antibody. Suitable for WB and reacts with Human, Rat, Chinese hamster samples. Immunogen corresponding to Synthetic Peptide within Human MMP26.

View Alternative Names

Matrix metalloproteinase-26, MMP-26, Endometase, Matrilysin-2, MMP26

1 Images
Western blot - Anti-MMP26 Antibody [S01-7A4] (AB317391)
  • WB

Supplier Data

Western blot - Anti-MMP26 Antibody [S01-7A4] (AB317391)

Observed band corresponds to 19 kDa full length mature chain without signal peptide or propeptide.

All lanes:

Western blot - Anti-MMP26 Antibody [S01-7A4] (ab317391) at 1/500 dilution

Lane 1:

Jurkat cell lysate

Lane 2:

C6 cell lysate

Lane 3:

CHO-K1 cell lysate

Predicted band size: 30 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

S01-7A4

Isotype

IgG

Carrier free

No

Reacts with

Human, Rat, Chinese hamster

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MMP26.

Q9NRE1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Chinese hamster": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP26 also known as matrix metalloproteinase-26 or endometase is an enzyme that degrades components of the extracellular matrix. This metalloproteinase part of the larger MMP family has a mass of approximately 28 kDa. MMP26 expresses in various tissues notably in the uterus and specific cancerous cells. The enzyme's primary function involves breaking down proteins such as collagen and gelatin contributing to tissue remodeling and repair processes.
Biological function summary

MMP26 plays a critical role in cellular responses that require remodeling of the extracellular matrix. It is part of the metalloproteinase family which function as zinc-dependent endopeptidases. MMP26 often forms complexes with tissue inhibitors of metalloproteinases (TIMPs) which regulate its activity. This regulatory mechanism is vital in maintaining a balance between matrix degradation and deposition important for normal physiological processes like wound healing and embryogenesis.

Pathways

MMP26 associates intricately with extracellular matrix degradation and tissue remodeling pathways. One important pathway includes the regulation of the extracellular matrix organization. The enzyme interacts closely with other matrix metalloproteinases such as MMP9 and MMP2 which also play roles in similar pathways contributing to various biological processes like cell migration and angiogenesis.

MMP26 shows a notable connection to cancer progression and metastasis. The enzymatic activity of MMP26 enables cancerous cells to invade surrounding tissues by degrading the extracellular matrix. This characteristic links the enzyme to breast cancer where it often shows overexpression. MMP26 also associates with other metalloproteinases like MMP9 in the tumor microenvironment influencing tumor growth and invasion.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.
See full target information MMP26
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