AB216631

Anti-MMP7 antibody

Name: Anti-MMP7 antibody (ab216631) | Abcam
Brand: Abcam Limited
SKU: AB216631
Price: 525 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal MMP7 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human MMP7 aa 150-250 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

MPSL1, PUMP1, MMP7, Matrilysin, Matrin, Matrix metalloproteinase-7, Pump-1 protease, Uterine metalloproteinase, MMP-7

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP7 antibody (AB216631)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP7 antibody (AB216631)

Immunohistochemical analysis of formalin-fixed and paraffin embedded human colon carcinoma tissue labeling MMP7 using ab216631 at 1/200, followed by secondary detection and DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP7 antibody (AB216631)

Immunohistochemical analysis of formalin-fixed and paraffin embedded human colon carcinoma tissue labeling MMP7 using ab216631 at 1/200, followed by secondary detection and DAB staining.

Supplier Data

Western blot - Anti-MMP7 antibody (AB216631)

All lanes:

Western blot - Anti-MMP7 antibody (ab216631) at 1/300 dilution

All lanes:

mouse uterus lysate

Predicted band size: 29 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human MMP7 aa 150-250 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P09237

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP7 also known as matrilysin is a member of the matrix metalloproteinase family and has a molecular weight of approximately 28 kDa. Mechanically MMP7 participates in the breakdown of extracellular matrix components such as elastin casein and various collagens. It is important in tissue remodeling processes. MMP7 is expressed in multiple tissues including the glandular epithelia of the breast prostate and lung.

Biological function summary

MMP7 participates in wound healing embryonic development and tissue invasion processes. It does not typically form large complexes but can interact with other ECM components and inhibitors like TIMPs (tissue inhibitors of metalloproteinases). MMP7 has specific roles in regulating cellular environments by modifying the ECM and influencing the bioavailability of growth factors.

Pathways

MMP7 plays significant roles in pathways like the Wnt and MAPK signaling pathways. In the Wnt pathway MMP7 modulates the availability of bound matrix proteins influencing signaling dynamics. It interacts with proteins such as B-catenin and influences downstream gene expression. In the context of MAPK pathways MMP7 activity can lead to signal transduction changes that impact cell proliferation and migration.

MMP7 has associations with cancer progression and fibrosis. In colorectal cancer for example MMP7 expression levels correlate with tumor invasion and metastasis. It interacts with proteins like E-cadherin which affects cell adhesion properties and promotes disease advancement. In pulmonary fibrosis excessive MMP7 activity contributes to matrix degradation and aberrant tissue repair highlighting its relevance in pathological conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

See full target information MMP7

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 21:817 PubMed37974228

2023

HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell proliferation and metastasis via PI3K/AKT signaling pathway in human anaplastic thyroid carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Zhong,Fan Yu,Ling Yang,Yu Wang,Lin Liu,Chengyou Jia,Haidong Cai,Jianshe Yang,Shiyang Sheng,Zhongwei Lv,Li Weng,Bo Wu,Xiaoping Zhang

Journal of oncology 2023:5093941 PubMed36866240

2023

Retinoblastoma-Binding Protein 5 Regulates H3K4 Methylation Modification to Inhibit the Proliferation of Melanoma Cells by Inactivating the Wnt/-Catenin and Epithelial-Mesenchymal Transition Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiqin Yang,Yue Jia,Shaojia Wang,Yongjun Zhang,Wen Fan,Xin Wang,Liang He,Xiaoyu Shen,Xiangqun Yang,Yi Zhang,Hongying Yang

Bioengineered 13:8064-8075 PubMed35291909

2022

RAB26 contributes to the progression of non-small cell lung cancer after being transcriptionally activated by SMAD3.

Applications

Unspecified application

Species

Unspecified reactive species

Haixia Ren,Bo Yang,Mingjiang Li,Chunling Lu,Xiaoping Li

American journal of physiology. Gastrointestinal a 317:G682-G693 PubMed31433212

2019

Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases.

Applications

Unspecified application

Species

Unspecified reactive species

Nicholas Osborne,Rebecca Sundseth,Martha D Gay,Hong Cao,Robin D Tucker,Sandeep Nadella,Shangzi Wang,Xunxian Liu,Alexander Kroemer,Lynda Sutton,Allen Cato,Jill P Smith

Reproduction (Cambridge, England) 157:475-484 PubMed30817320

2019

VIP activates primordial follicles of rat through ERK-mTOR pathway in tissue culture.

Applications

Unspecified application

Species

Unspecified reactive species

Song Li,Qi Fan,Yanqiu Xie,Haiyan Lin,Qi Qiu,Yihua Liang,Qingxue Zhang

View all publications

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Product promise

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