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AB232737

Anti-MMP7 antibody

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(4 Publications)

Rabbit Polyclonal MMP7 antibody. Suitable for WB, IHC-P and reacts with Human, Recombinant full length protein - Human, Mouse, Pig samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MMP7.

View Alternative Names

MPSL1, PUMP1, MMP7, Matrilysin, Matrin, Matrix metalloproteinase-7, Pump-1 protease, Uterine metalloproteinase, MMP-7

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP7 antibody (AB232737)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP7 antibody (AB232737)

Formalin-fixed, paraffin-embedded human kidney tissue stained for MMP7 using ab232737 at 20 μg/mL in immunohistochemical analysis. DAB staining.

Western blot - Anti-MMP7 antibody (AB232737)
  • WB

Supplier Data

Western blot - Anti-MMP7 antibody (AB232737)

All lanes:

Western blot - Anti-MMP7 antibody (ab232737) at 3 µg/mL

All lanes:

Recombinant human MMP7 protein

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit Ab at 1/2000 dilution

Predicted band size: 29 kDa

false

Western blot - Anti-MMP7 antibody (AB232737)
  • WB

Supplier Data

Western blot - Anti-MMP7 antibody (AB232737)

All lanes:

Western blot - Anti-MMP7 antibody (ab232737) at 3 µg/mL

Lane 1:

Human urine

Lane 2:

Pig lung lysate

Lane 3:

Mouse placenta lysate

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit Ab at 1/2000 dilution

Predicted band size: 29 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MMP7.

P09237

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP7 also known as matrilysin is a member of the matrix metalloproteinase family and has a molecular weight of approximately 28 kDa. Mechanically MMP7 participates in the breakdown of extracellular matrix components such as elastin casein and various collagens. It is important in tissue remodeling processes. MMP7 is expressed in multiple tissues including the glandular epithelia of the breast prostate and lung.
Biological function summary

MMP7 participates in wound healing embryonic development and tissue invasion processes. It does not typically form large complexes but can interact with other ECM components and inhibitors like TIMPs (tissue inhibitors of metalloproteinases). MMP7 has specific roles in regulating cellular environments by modifying the ECM and influencing the bioavailability of growth factors.

Pathways

MMP7 plays significant roles in pathways like the Wnt and MAPK signaling pathways. In the Wnt pathway MMP7 modulates the availability of bound matrix proteins influencing signaling dynamics. It interacts with proteins such as B-catenin and influences downstream gene expression. In the context of MAPK pathways MMP7 activity can lead to signal transduction changes that impact cell proliferation and migration.

MMP7 has associations with cancer progression and fibrosis. In colorectal cancer for example MMP7 expression levels correlate with tumor invasion and metastasis. It interacts with proteins like E-cadherin which affects cell adhesion properties and promotes disease advancement. In pulmonary fibrosis excessive MMP7 activity contributes to matrix degradation and aberrant tissue repair highlighting its relevance in pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
See full target information MMP7
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:2152 PubMed39820824

2025

Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights.

Applications

Unspecified application

Species

Unspecified reactive species

Lingxia Wu,Chenxiaoxiao Liu,Weicai Hu

Nature cardiovascular research 2:629-644 PubMed39195920

2023

The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Zhang,Yumeng Zhang,Evelyn Hutterer,Sara Hultin,Otto Bergman,Solrun Kolbeinsdottir,Hong Jin,Maria J Forteza,Daniel F J Ketelhuth,Joy Roy,Ulf Hedin,Martin Enge,Ljubica Matic,Per Eriksson,Lars Holmgren

Cellular and molecular gastroenterology and hepatology 16:39-62 PubMed37030630

2023

PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Vinicius Canale,Marianne R Spalinger,Rocio Alvarez,Anica Sayoc-Becerra,Golshid Sanati,Salomon Manz,Pritha Chatterjee,Alina N Santos,Hillmin Lei,Sharon Jahng,Timothy Chu,Ali Shawki,Elaine Hanson,Lars Eckmann,André J Ouellette,Declan F McCole

Molecular therapy. Nucleic acids 23:1078-1092 PubMed33614250

2021

Hypoxic tumor-derived exosomal circular RNA SETDB1 promotes invasive growth and EMT via the miR-7/Sp1 axis in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Li Xu,Wei-Lin Liao,Qi-Jue Lu,Peng Zhang,Ji Zhu,Ge-Ning Jiang
View all publications
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Product promise

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