AB189277

Anti-MMP7 antibody - C-terminal

Name: Anti-MMP7 antibody - C-terminal (ab189277) | Abcam
Brand: Abcam Limited
SKU: AB189277
Price: 630 USD
Availability: InStock

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(6 Publications)

Rabbit Polyclonal MMP7 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human, African green monkey samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human MMP7 aa 200 to C-terminus.

View Alternative Names

MPSL1, PUMP1, MMP7, Matrilysin, Matrin, Matrix metalloproteinase-7, Pump-1 protease, Uterine metalloproteinase, MMP-7

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP7 antibody - C-terminal (AB189277)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP7 antibody - C-terminal (AB189277)

Immunohistochemistry of formalin-fixed, paraffin-embedded Human uterus tissue labeling MMP7 with ab189277 at 10 μg/ml.

Supplier Data

Western blot - Anti-MMP7 antibody - C-terminal (AB189277)

All lanes:

Western blot - Anti-MMP7 antibody - C-terminal (ab189277) at 1/500 dilution

Lane 1:

COS-7 (African green monkey kidney fibroblast-like cell line) cell lysate

Lane 2:

COS-7 (African green monkey kidney fibroblast-like cell line) cell lysate with synthesized peptide

Predicted band size: 29 kDa,39 kDa

Observed band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human, African green monkey

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human MMP7 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P09237

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "African green monkey": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP7 also known as matrilysin is a member of the matrix metalloproteinase family and has a molecular weight of approximately 28 kDa. Mechanically MMP7 participates in the breakdown of extracellular matrix components such as elastin casein and various collagens. It is important in tissue remodeling processes. MMP7 is expressed in multiple tissues including the glandular epithelia of the breast prostate and lung.

Biological function summary

MMP7 participates in wound healing embryonic development and tissue invasion processes. It does not typically form large complexes but can interact with other ECM components and inhibitors like TIMPs (tissue inhibitors of metalloproteinases). MMP7 has specific roles in regulating cellular environments by modifying the ECM and influencing the bioavailability of growth factors.

Pathways

MMP7 plays significant roles in pathways like the Wnt and MAPK signaling pathways. In the Wnt pathway MMP7 modulates the availability of bound matrix proteins influencing signaling dynamics. It interacts with proteins such as B-catenin and influences downstream gene expression. In the context of MAPK pathways MMP7 activity can lead to signal transduction changes that impact cell proliferation and migration.

MMP7 has associations with cancer progression and fibrosis. In colorectal cancer for example MMP7 expression levels correlate with tumor invasion and metastasis. It interacts with proteins like E-cadherin which affects cell adhesion properties and promotes disease advancement. In pulmonary fibrosis excessive MMP7 activity contributes to matrix degradation and aberrant tissue repair highlighting its relevance in pathological conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

See full target information MMP7

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Physiological reports 12:e16157 PubMed39085755

2024

Exosomal miR-106a-5p derived from intermittently hypoxic non-small-cell lung cancer increases tumor malignancy.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Ren,Zhuan Jin,Yongjie Huang

Journal of oncology 2019:7630894 PubMed31428151

2019

Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jinghui Yang,Xianling Cong,Ming Ren,Hongyan Sun,Tao Liu,Gaoyang Chen,Qingyu Wang,Zhaoyan Li,Shan Yu,Qiwei Yang

International journal of biological sciences 15:556-567 PubMed30745842

2019

Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhang,Jin-Xiu Zhu,Zhen-Guo Ma,Hai-Ming Wu,Si-Chi Xu,Peng Song,Chun-Yan Kong,Yu-Pei Yuan,Wei Deng,Qi-Zhu Tang

Cellular physiology and biochemistry : internation 46:36-45 PubMed29566360

2018

The Antimuscarinic Agent Tolterodine Regulates Bladder Extracellular Matrix in Partial Bladder Outlet Obstruction in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Tong-Xin Yang,De-Yi Luo,Yi-Fei Lin,Qiang Liu,Xiang Cai,Jian-Zhong Ai,Hong Li,Hong Shen,Kun-Jie Wang

Molecular medicine reports 16:6967-6973 PubMed28901395

2017

Role of matrix metalloproteinase‑7 and apoptosis‑associated gene expression levels in the pathogenesis of atrial fibrosis in a Beagle dog model.

Applications

Unspecified application

Species

Unspecified reactive species

Min Jia,Zai-Bo Li,Lin Li,Hong-Tao Chu,Zhuang-Zhuang Li

American journal of translational research 8:5569-5579 PubMed28078027

2016

Advanced glycosylation end product promotes forkhead box O1 and inhibits Wnt pathway to suppress capacities of epidermal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Zhu,Peng Wang,Zhimin Yu,Wei Lai,Yi Cao,Pinbo Huang,Qiaodong Xu,Menglei Yu,Junyao Xu,Zitong Huang,Bing Zeng

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-MMP7 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP7 antibody - C-terminal (AB189277)

Western blot - Anti-MMP7 antibody - C-terminal (AB189277)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

Product promise