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AB235395

Anti-MND1 antibody

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(1 Publication)

Rabbit Polyclonal MND1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MND1.

View Alternative Names

GAJ, MND1, Meiotic nuclear division protein 1 homolog

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MND1 antibody (AB235395)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MND1 antibody (AB235395)

Paraffin-embedded human gastric cancer tissue stained for MND1 with ab235395 (1/100 dilution) in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MND1 antibody (AB235395)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MND1 antibody (AB235395)

Paraffin-embedded human endometrial cancer tissue stained for MND1 with ab235395 (1/100 dilution) in immunohistochemical analysis.

Western blot - Anti-MND1 antibody (AB235395)
  • WB

Supplier Data

Western blot - Anti-MND1 antibody (AB235395)

All lanes:

Western blot - Anti-MND1 antibody (ab235395) at 1/1000 dilution

All lanes:

Jurkat (Human T cell leukemia cell line from peripheral blood) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 24 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MND1.

Q9BWT6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MND1 protein also known by its full name Meiotic Nuclear Divisions 1 plays a mechanical role in the process of homologous recombination. Its molecular mass is approximately 25 kDa which is quite small. MND1 expresses in germ cells specifically during the meiotic phase of cell division. This expression has been noted in both male and female gametogenesis which is essential for proper chromosomal synapsis and disassembly.
Biological function summary

MND1 works alongside other proteins to ensure successful meiotic recombination. It often forms a complex with the protein HOP2 which enhances its function. This complex improves the pairing and alignment of homologous chromosomes during meiosis. Through this interaction MND1 influences genetic diversity by allowing the exchange of genetic material between chromosomes a necessary process for the formation of viable gametes.

Pathways

MND1 interacts within genetic recombination pathways that are important for accurate chromosome segregation. It performs important functions in the homologous recombination repair pathway. Specifically the MND1-HOP2 complex works closely with proteins such as RAD51 and DMC1 which are also involved in DNA repair and strand invasion during meiosis. These interactions facilitate the correction of DNA double-strand breaks ensuring stability and integrity of the genetic material.

Mutations or malfunctions in MND1 can lead to meiotic arrest and infertility. Research indicates that improper function or expression of MND1 may be implicated in certain cases of sterility in both males and females. The MND1-HOP2 complex has shown associations with these fertility issues highlighting its importance in normal reproductive health. Understanding the MND1 pathway could potentially lead to new insights into treatments for infertility issues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
See full target information MND1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 14:7416-7442 PubMed36098680

2022

MND1 functions as a potential prognostic biomarker associated with cell cycle and immune infiltration in kidney renal clear cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jiayu Fang,Jing Zhen,Yiyang Gong,Yun Ke,Bidong Fu,Yike Jiang,Jing Xie,Yue Liu,Yongqi Ding,Da Huang,Fan Xiao
View all publications
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