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AB230013

Anti-MOCS2 antibody

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(1 Publication)

Rabbit Polyclonal MOCS2 antibody. Suitable for IP, WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MOCS2.

View Alternative Names

MCBPE, MOCO1, MOCS2, Molybdopterin synthase catalytic subunit, MOCO1-B, Molybdenum cofactor synthesis protein 2 large subunit, Molybdenum cofactor synthesis protein 2B, Molybdopterin-synthase large subunit, MOCS2B, MPT synthase large subunit

5 Images
Immunocytochemistry/ Immunofluorescence - Anti-MOCS2 antibody (AB230013)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-MOCS2 antibody (AB230013)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for MOCS2 (green) using ab230013 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® congugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOCS2 antibody (AB230013)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOCS2 antibody (AB230013)

Paraffin-embedded human kidney tissue stained for ab230013 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOCS2 antibody (AB230013)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOCS2 antibody (AB230013)

Paraffin-embedded human adrenal gland tissue stained for MOCS2 using ab230013 at 1/100 dilution in immunohistochemical analysis.

Immunoprecipitation - Anti-MOCS2 antibody (AB230013)
  • IP

Supplier Data

Immunoprecipitation - Anti-MOCS2 antibody (AB230013)

MOCS2 was immunoprecipitated from 500 μg Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate with 4 μg of ab230013.

Lane 1 : 1 μg of rabbit monoclonal IgG instead of ab230013 in Jurkat whole cell lysate.

Lane 2 : ab230013 IP in jurkat whole cell lysate.

Lane 3 : Jurkat whole cell lysate 20 μg (input).

For western blotting, an HRP-conjugated light chain specific antibody was used as the Secondary antibody at 1/50000 dilution.

All lanes:

Immunoprecipitation - Anti-MOCS2 antibody (ab230013)

Predicted band size: 21 kDa

false

Western blot - Anti-MOCS2 antibody (AB230013)
  • WB

Supplier Data

Western blot - Anti-MOCS2 antibody (AB230013)

All lanes:

Western blot - Anti-MOCS2 antibody (ab230013) at 1/1000 dilution

Lane 1:

A549 (human lung carcinoma cell line) whole cell lysate

Lane 2:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 21 kDa

Observed band size: 21 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MOCS2.

O96007

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/200 - 1/2000", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MOCS2 also known as molybdenum cofactor synthesis 2 plays a mechanical role in the biosynthesis of molybdenum cofactor. The protein has a molecular mass of approximately 20 kDa. MOCS2 is mainly expressed in the liver and kidneys where it contributes to various cellular processes. It consists of two isoforms A and B which play unique roles in facilitating the conversion of precursor molecules into active cofactors.
Biological function summary

The molybdenum cofactor synthesis process requires several components to function effectively. MOCS2 is part of the molybdenum cofactor synthesis complex which is essential for proper enzyme activity that utilizes the molybdenum cofactor. Enzymes requiring this cofactor include xanthine oxidase and aldehyde oxidase both of which are critical for metabolizing purines and aldehydes. The formation and regulation of this complex ensure efficient enzyme activity across different tissues.

Pathways

MOCS2 participates in the molybdenum cofactor biosynthesis pathway. It aligns with the sulfur transfer pathway where it interacts closely with MOCS1 another molybdenum cofactor synthesis protein. Both proteins coordinate to ensure sufficient cofactor production for catalytic reactions. These interactions allow for the proper function of enzymes like sulfite oxidase linking MOCS2 to essential metabolic processes.

Mutations or dysfunction in MOCS2 can lead to molybdenum cofactor deficiency a rare metabolic disorder. This disorder results in neurological symptoms due to the accumulation of toxic substances unmetabolized due to insufficient cofactor. MOCS2’s relationship with MOCS1 is significant as alterations in either can cause similar metabolic disruptions leading to the disease. Understanding MOCS2's role in these pathways provides insights into therapeutic strategies for affected individuals.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
See full target information MOCS2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 16:324 PubMed40597299

2025

Mesenchymal stromal cell secretome reduces lung injury and thrombo-inflammation induced by SARS-CoV-2 spike protein.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Pezzotta,Alessandra Bovio,Barbara Imberti,Monica Locatelli,Daniela Corna,Domenico Cerullo,Sara Gastoldi,Ariela Benigni,Giuseppe Remuzzi,Marina Morigi,Luca Perico
View all publications
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Complementary Products

Proteins & Peptides

AB134527

Recombinant Human MOCS2 protein

SDS-PAGE - Recombinant Human MOCS2 protein (AB134527)

  • 0
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Product promise

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