AB33451

Anti-Monocyte + Macrophage antibody [MOMA-2]

Name: Anti-Monocyte + Macrophage antibody [MOMA-2] (ab33451) | Abcam
Brand: Abcam Limited
SKU: AB33451
Price: 500 USD
Availability: InStock
Rating: 4 (3 reviews)

(3 Reviews)

(124 Publications)

Rat Monoclonal Mouse Macrophage antibody. Suitable for Flow Cyt, IHC-FoFr, IHC-P, IHC-Fr and reacts with Mouse samples. Cited in 124 publications.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

MOMA-2

Isotype

IgG2b

Carrier free

Reacts with

Mouse

Applications

IHC-P, Flow Cyt, IHC-FoFr, IHC-Fr

applications

Specificity

This antibody recognises an intracellular antigen of mouse macrophages and monocytes. It reacts strongly with macrophages in lymphoid organs in all mouse strains tested. Staining may also be seen on the epithelium of mucosa.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "Membrane permeabilisation is required for this application. ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.", "IHCFoFr-species-checked": "guaranteed", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

Preservative: 0.09% Sodium azide

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Monocytes and macrophages often referred to as MO or MOMa-2 are types of white blood cells that play essential roles in the immune system. Monocytes which express various mouse monocyte markers develop in the bone marrow and circulate in the bloodstream. They typically measure about 12 to 15 micrometers in diameter. Monocytes migrate to tissues where they differentiate into macrophages. These macrophages are larger typically 20 micrometers and reside in tissues throughout the body. Macrophages are characterized by their large irregular shape and possess a great ability to engulf pathogens and debris.

Biological function summary

Monocytes and macrophages help protect the body from infection and clear injured tissue. They operate as part of the innate immune response and also contribute to the adaptive immune response. Macrophages in particular are known for their phagocytic activity where they engulf and digest microorganisms cellular debris and other particles. They secrete cytokines and chemokines that recruit other immune cells to sites of infection or injury. Monocyte to macrophage differentiation allows for the transformation from a circulating cell to a tissue-resident cell adapting to specific tissue functions.

Pathways

Monocytes and macrophages are integral to the inflammatory and immune response pathways. These cells are involved in the Toll-like receptor (TLR) signaling pathway which detects pathogens and initiates immune defense mechanisms. They also participate in the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway regulating cytokine production and cell survival. Macrophages interact with a wide range of proteins including tumor necrosis factor-alpha (TNF-α) which plays an essential role in inflammation and apoptosis.

Monocytes and macrophages are linked to chronic inflammatory diseases and infections. Their dysfunction or overactivation has been observed in disorders like atherosclerosis and rheumatoid arthritis. In atherosclerosis macrophages accumulate lipids becoming foam cells and contributing to plaque development with an interaction seen with low density lipoprotein (LDL). In rheumatoid arthritis macrophages release pro-inflammatory cytokines exacerbating joint inflammation and damage often relating to the presence of interleukin-1 (IL-1).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Mouse Macrophage

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Publications (124)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 15:4016-4032 PubMed40213658

2025

Augmented expression of superoxide dismutase 2 mitigates progression and rupture of experimental abdominal aortic aneurysm.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Yan,Ying Hu,Yang Lyu,Antonina Akk,Angela C Hirbe,Samuel A Wickline,Hua Pan,Elisha D O Roberson,Christine T N Pham

Cellular and molecular life sciences : CMLS 82:134 PubMed40159437

2025

Dysregulated cholesterol uptake and efflux of bone marrow-derived α-SMA macrophages contribute to atherosclerotic plaque formation.

Applications

Unspecified application

Species

Unspecified reactive species

Menglu Li,Lili Wu,Yuxin Wen,Anni Wang,Xiao Zhou,Lijie Ren,Qiongyu Lu,Fengchan Li,Li Zhu,Chaojun Tang

Metabolic brain disease 40:133 PubMed40019557

2025

Combined treatment of Ketogenic diet and propagermanium reduces neuroinflammation in Tay-Sachs disease mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Orhan Kerim Inci,Volkan Seyrantepe

NPJ biofilms and microbiomes 11:12 PubMed39794320

2025

Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuyuki Kasahara,Robert L Kerby,Ruben Aquino-Martinez,Abigail H Evered,Tzu-Wen L Cross,Jessica Everhart,Tyler K Ulland,Colin D Kay,Bradley W Bolling,Fredrik Bäckhed,Federico E Rey

Drug design, development and therapy 18:6389-6411 PubMed39749190

2025

Qingre Huoxue Decoction Alleviates Atherosclerosis by Regulating Macrophage Polarization Through Exosomal miR-26a-5p.

Applications

Unspecified application

Species

Unspecified reactive species

Weifeng He,Huanyi Zhao,Weiqi Xue,Yuan Luo,Mengyuan Yan,Junlong Li,Lijin Qing,Wei Wu,Zheng Jin

International journal of biological sciences 20:3691-3709 PubMed39113704

2024

Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Kai Hong,Tsung-Lin Cheng,Chao-Kai Hsu,Fang-Tzu Lee,Bi-Ing Chang,Kuan-Chieh Wang,Lan-Yun Chang,Hua-Lin Wu,Chao-Han Lai

Biomedicines 12: PubMed38927458

2024

Formation of Multinucleated Giant Cells after Experimental Intracerebral Hemorrhage: Characteristics and Role of Complement C3.

Applications

Unspecified application

Species

Unspecified reactive species

Xiongjie Fu,Ming Wang,Yingfeng Wan,Ya Hua,Richard F Keep,Guohua Xi

iScience 27:109849 PubMed38784008

2024

TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage.

Applications

Unspecified application

Species

Unspecified reactive species

Xuyang Wang,Yuesheng Zhang,Luping Du,Zhengchen Jiang,Yan Guo,Kai Wang,Yijiang Zhou,Xiang Yin,Xiaogang Guo

Nature cardiovascular research 3:389-402 PubMed38737787

2024

The PD-1-PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Vargas Aguilar,Miao Cui,Wei Tan,Efrain Sanchez-Ortiz,Rhonda Bassel-Duby,Ning Liu,Eric N Olson

Diabetology & metabolic syndrome 16:98 PubMed38715117

2024

miR-449a disturbs atherosclerotic plaque stability in streptozotocin and high-fat diet-induced diabetic mice by targeting CEACAM1.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Yu,Han Liu,Yu Chen,Ling Wang,Peng Chen,Yue Zhao,Chunxia Ou,Wei Chen,Jie Hu,Yu Wang,Yan Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Monocyte + Macrophage antibody [MOMA-2]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (124)

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Product promise