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AB76813

Anti-MORC3 antibody

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(2 Publications)

Mouse Polyclonal MORC3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MORC3.

View Alternative Names

KIAA0136, NXP2, ZCWCC3, MORC3, MORC family CW-type zinc finger protein 3, Nuclear matrix protein 2, Zinc finger CW-type coiled-coil domain protein 3

2 Images
Western blot - Anti-MORC3 antibody (AB76813)
  • WB

Unknown

Western blot - Anti-MORC3 antibody (AB76813)

All lanes:

Western blot - Anti-MORC3 antibody (ab76813) at 1/500 dilution

All lanes:

nuclear extracts from Hela cells at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L) HRP-conjugated at 1/2500 dilution

Predicted band size: 107 kDa

Observed band size: 125 kDa

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Western blot - Anti-MORC3 antibody (AB76813)
  • WB

Unknown

Western blot - Anti-MORC3 antibody (AB76813)

All lanes:

Western blot - Anti-MORC3 antibody (ab76813) at 1/500 dilution

Lane 1:

MORC3 transfected 293T cell lysate at 25 µg

Lane 2:

Non transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L) HRP-conjugated at 1/2500 dilution

Predicted band size: 107 kDa

Observed band size: 125 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MORC3.

Q14149

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MORC3 also known as Microrchidia CW-type zinc finger protein 3 is a nuclear protein with a molecular weight of approximately 100 kDa. It functions as part of chromatin remodeling processes and is found within the nucleus of cells. MORC3 exhibits a high level of expression in testes and other tissues supporting its role in transcription regulation and nuclear body formation. It also contains several domains such as ATPase zinc finger and a nuclear localization signal which are critical for its mechanical action within the cell.
Biological function summary

MORC3 influences nuclear dynamics and chromatin organization. It plays a central role in the formation of promyelocytic leukemia nuclear bodies (PML-NBs) which are involved in gene regulation DNA repair and apoptosis. MORC3 can interact with proteins within PML-NBs indicating it’s part of a protein complex that maintains genomic stability. This organizational role supports various cellular processes by regulating gene expression patterns in response to stress and damage.

Pathways

MORC3 integrates into different signaling pathways including DNA damage response and gene repression-specific pathways. It participates in the p53 signaling pathway where its interaction with proteins like p300 influences transcriptional activation of p53 target genes. Moreover MORC3's involvement in these pathways highlights processes such as cell cycle regulation apoptosis and maintenance of genomic integrity under stress conditions.

MORC3 has been associated with autoimmune conditions and cancer. Variants or dysregulation in MORC3 expression can relate to systemic lupus erythematosus where it impacts immune responses through proteins like TRIM21 known for its role in autoimmunity. Additionally changes in MORC3 expression levels have correlations with certain cancer types where aberrant nuclear body formation affects cell proliferation and survival mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed : 27440897, PubMed : 34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed : 34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed : 17332504, PubMed : 20501696). Binds RNA in vitro (PubMed : 11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed : 26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed : 26933034).. (Microbial infection) May be required for influenza A transcription during viral infection (PubMed : 26202233).
See full target information MORC3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 89:10023-30 PubMed26202233

2015

The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication.

Applications

Unspecified application

Species

Unspecified reactive species

Lorena S Ver,Laura Marcos-Villar,Sara Landeras-Bueno,Amelia Nieto,Juan Ortín

Annals of the rheumatic diseases 71:710-3 PubMed22258483

2012

Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy.

Applications

WB

Species

Human

Yuki Ichimura,Takashi Matsushita,Yasuhito Hamaguchi,Kenzo Kaji,Minoru Hasegawa,Yoshinori Tanino,Yayoi Inokoshi,Kazuhiro Kawai,Takuro Kanekura,Maria Habuchi,Atsuyuki Igarashi,Ryosuke Sogame,Takashi Hashimoto,Tomohiro Koga,Ayako Nishino,Naoko Ishiguro,Naoki Sugimoto,Rui Aoki,Noriko Ando,Tetsuya Abe,Takashi Kanda,Masataka Kuwana,Kazuhiko Takehara,Manabu Fujimoto
View all publications
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