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AB121099

Anti-MORC4 antibody

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(2 Publications)

Rabbit Polyclonal MORC4 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MORC4 aa 650-800.

View Alternative Names

ZCW4, ZCWCC2, MORC4, MORC family CW-type zinc finger protein 4, Zinc finger CW-type coiled-coil domain protein 2, Zinc finger CW-type domain protein 4

3 Images
Western blot - Anti-MORC4 antibody (AB121099)
  • WB

Supplier Data

Western blot - Anti-MORC4 antibody (AB121099)

All lanes:

Western blot - Anti-MORC4 antibody (ab121099) at 0.4 µg/mL

All lanes:

A549 cell lysate

Predicted band size: 106 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MORC4 antibody (AB121099)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MORC4 antibody (AB121099)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling MORC4 with ab121099. Staining shows moderate nuclear positivity in a subset of cells in seminiferous ducts.

Immunocytochemistry/ Immunofluorescence - Anti-MORC4 antibody (AB121099)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MORC4 antibody (AB121099)

Immunocytochemistry/immunofluorescence analysis of Caco-2 cells labelling MORC4 with ab121099 shows positive staining in the nucleus but excluded from the nucleoli.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MORC4 aa 650-800. The exact immunogen used to generate this antibody is proprietary information.

Q8TE76

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p>Perform heat mediated antigen retrieval via the pressure cooker method.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MORC4 also known as MORC family CW-type zinc finger protein 4 is a protein that plays a role in chromatin remodeling and DNA isolation. MORC4 has an approximate molecular mass of 117 kDa. Expression occurs widely but is especially present in tissues such as testis and ovary indicating its involvement in reproductive processes. This distribution hints that MORC4 may have a specialized function in regulating gene expression within these cells.
Biological function summary

MORC4 functions as part of the chromatin remodeling complex which influences gene transcription by modifying the chromatin structure. It acts by binding to particular DNA sequences and altering chromatin's accessibility. MORC4 interacts with other proteins in the complex such as histone acetyltransferases and deacetylases which further adjust chromatin structure and recruit additional factors important for gene regulation.

Pathways

MORC4 is an active participant in the DNA repair and signal transduction pathways. It supports DNA repair mechanisms through its interaction with repair-related proteins like PARP1. Additionally MORC4 influences the MAPK signaling pathway working with proteins such as ERK1/2 which are key in cell proliferation and stress responses.

MORC4 has associations with certain cancers and infertility. Mutations or dysregulation in MORC4 expression relate to some cancer types including ovarian and testicular cancer due to its role in cell cycle progression and apoptosis. Furthermore abnormalities in MORC4 may contribute to infertility connecting with proteins like BRCA1 that influence DNA damage repair an essential process for maintaining healthy reproductive cells.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed : 26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed : 26933034).
See full target information MORC4
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

OncoTargets and therapy 12:11183-11193 PubMed31908485

2019

Baicalin Inhibits Cell Viability, Migration and Invasion in Breast Cancer by Regulating miR-338-3p and MORC4.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Duan,Guangcheng Guo,Xinhong Pei,Xinxing Wang,Lin Li,Youyi Xiong,Xinguang Qiu

Molecular medicine reports 14:1451-8 PubMed27357608

2016

Reciprocal regulation of long noncoding RNAs THBS4‑003 and THBS4 control migration and invasion in prostate cancer cell lines.

Applications

Unspecified application

Species

Unspecified reactive species

Jinliang Liu,Gong Cheng,Haiwei Yang,Xiaheng Deng,Chao Qin,Lixin Hua,Changjun Yin
View all publications
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Product promise

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