Rabbit Polyclonal MOSC2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MTARC2 aa 200-300.
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Publications
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- Frontiers in genetics 12:7900932022Downregulation of MARC2 Promotes Immune Escape and Is Associated With Immunosuppression of Hepatocellular Carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDehai Wu,Shuhang Liang,Hongrui Guo,Shugeng Zhang,Guangchao Yang,Yubin Yuan,Lianxin LiuPubMed 35173763
- Oncogene 39:6099-61122020A novel mitochondrial amidoxime reducing component 2 is a favorable indicator of cancer and suppresses the progression of hepatocellular carcinoma by regulating the expression of p27.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDehai Wu et. al.PubMed 32811980
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human MTARC2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q969Z3
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
| Cynomolgus monkey | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cynomolgus monkey | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cynomolgus monkey | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045).
Alternative names
Mitochondrial amidoxime reducing component 2, mARC2, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2, MTARC2, MOSC2, MARC2
Recommended products
Rabbit Polyclonal MOSC2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MTARC2 aa 200-300.
Alternative names
Mitochondrial amidoxime reducing component 2, mARC2, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2, MTARC2, MOSC2, MARC2
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human MTARC2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q969Z3
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MOSC2 also known as CIAPIN1 or Mitochondrial amidoxime reducing component 2 is a protein encoded by the MOSC2 gene. This protein has a molecular weight of approximately 38 kDa. Mechanically MOSC2 acts as an oxidoreductase facilitating electron transfer across various substrates. MOSC2 is expressed in multiple tissues with higher expression observed in liver kidney and heart which suggests its diverse functional roles in different physiological contexts.
- Biological function summary
MOSC2 is part of a mitochondrial complex involved in metabolic processes. It plays a role in catalyzing the reduction of N-hydroxylated substrates linking electron transfer to cellular metabolism. The protein assists in the activation of pro-drugs by reducing N-hydroxylated intermediates. This function positions MOSC2 as a significant player in cellular metabolic pathways showcasing its involvement in the broader scheme of mitochondrial function and energy homeostasis.
- Pathways
MOSC2 participates in detoxification and mitochondrial respiratory pathways which are essential for maintaining cellular health. It plays a role in the mitochondrial amidoxime reducing component (mARC) pathway where it collaborates with cytochrome b5 and NADH cytochrome b5 reductase for electron transfer. This interaction highlights its necessity for redox reactions confirming its importance in maintaining the balance of reactive molecules within the cell.
- Associated diseases and disorders
MOSC2 has been implicated in metabolic disorders and certain cancers. Alterations in MOSC2 function or expression can affect mitochondrial metabolism potentially contributing to metabolic syndrome. Additionally its interactions with proteins such as NADH cytochrome b5 reductase can influence cancer cell metabolism suggesting a role in tumorigenesis. These associations highlight its potential as a therapeutic target in conditions where metabolic pathways are disrupted.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOSC2 antibody (ab224097)
Paraffin-embedded human liver tissue stained for MOSC2 using ab224097 at 1/500 in immunohistochemical analysis.
Western blot - Anti-MOSC2 antibody (ab224097)
All lanes: Western blot - Anti-MOSC2 antibody (ab224097) at 0.4 µg/mL
All lanes: Human cell line TD47D
Predicted band size: 38 kDa, 50 kDa, 60 kDa
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