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AB224398

Anti-MOSC2 antibody

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(1 Publication)

Rabbit Polyclonal MOSC2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MTARC2 aa 50-200.

View Alternative Names

MARC2, MOSC2, MTARC2, Mitochondrial amidoxime reducing component 2, mARC2, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOSC2 antibody (AB224398)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOSC2 antibody (AB224398)

Immunohistochemical analysis of paraffin-embedded human kidney tissue labeling MOSC2 with ab224398 at 1/50 dilution. Antigen retrieval was heat mediated with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOSC2 antibody (AB224398)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOSC2 antibody (AB224398)

Immunohistochemical analysis of paraffin-embedded human parathyroid gland tissue labeling MOSC2 with ab224398 at 1/50 dilution. Antigen retrieval was heat mediated with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOSC2 antibody (AB224398)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOSC2 antibody (AB224398)

Immunohistochemical analysis of paraffin-embedded human cerebral cortex tissue labeling MOSC2 with ab224398 at 1/50 dilution. Antigen retrieval was heat mediated with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOSC2 antibody (AB224398)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOSC2 antibody (AB224398)

Immunohistochemical analysis of paraffin-embedded human lymph node tissue labeling MOSC2 with ab224398 at 1/50 dilution. Antigen retrieval was heat mediated with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MTARC2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q969Z3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MOSC2 also known as CIAPIN1 or Mitochondrial amidoxime reducing component 2 is a protein encoded by the MOSC2 gene. This protein has a molecular weight of approximately 38 kDa. Mechanically MOSC2 acts as an oxidoreductase facilitating electron transfer across various substrates. MOSC2 is expressed in multiple tissues with higher expression observed in liver kidney and heart which suggests its diverse functional roles in different physiological contexts.
Biological function summary

MOSC2 is part of a mitochondrial complex involved in metabolic processes. It plays a role in catalyzing the reduction of N-hydroxylated substrates linking electron transfer to cellular metabolism. The protein assists in the activation of pro-drugs by reducing N-hydroxylated intermediates. This function positions MOSC2 as a significant player in cellular metabolic pathways showcasing its involvement in the broader scheme of mitochondrial function and energy homeostasis.

Pathways

MOSC2 participates in detoxification and mitochondrial respiratory pathways which are essential for maintaining cellular health. It plays a role in the mitochondrial amidoxime reducing component (mARC) pathway where it collaborates with cytochrome b5 and NADH cytochrome b5 reductase for electron transfer. This interaction highlights its necessity for redox reactions confirming its importance in maintaining the balance of reactive molecules within the cell.

MOSC2 has been implicated in metabolic disorders and certain cancers. Alterations in MOSC2 function or expression can affect mitochondrial metabolism potentially contributing to metabolic syndrome. Additionally its interactions with proteins such as NADH cytochrome b5 reductase can influence cancer cell metabolism suggesting a role in tumorigenesis. These associations highlight its potential as a therapeutic target in conditions where metabolic pathways are disrupted.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed : 21029045, PubMed : 24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed : 21029045, PubMed : 24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed : 21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed : 21029045).
See full target information MTARC2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Inflammation 45:1348-1361 PubMed35044570

2022

The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa.

Applications

Unspecified application

Species

Unspecified reactive species

Yosuke Shikama,Mie Kurosawa,Masae Furukawa,Yasusei Kudo,Naozumi Ishimaru,Kenji Matsushita
View all publications
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Product promise

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