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AB217287

Anti-Motilin receptor antibody

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(1 Publication)

Rabbit Polyclonal Motilin receptor antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MLNR aa 250-300 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

GPR38, MTLR, MTLR1, MLNR, Motilin receptor, G-protein coupled receptor 38

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Motilin receptor antibody (AB217287)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Motilin receptor antibody (AB217287)

Immunohistochemical analysis of formalin fixed, paraffin embedded Mouse stomach tissue labeling Motilin receptor with ab217287 at 1/200 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MLNR aa 250-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O43193

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The motilin receptor also known as GPR38 is a G-protein-coupled receptor (GPCR) with a molecular mass of approximately 45 kDa. This receptor primarily binds to motilin a peptide hormone. It is expressed in the smooth muscle cells of the gastrointestinal tract notably in areas like the stomach and small intestine. By coupling with G-proteins the motilin receptor initiates intracellular signaling cascades that result in physiological responses.
Biological function summary

The motilin receptor plays an important role in regulating gastrointestinal motility. This receptor upon binding motilin triggers contractions in the smooth muscles of the digestive tract. It does not form part of a larger receptor complex and functions independently to modulate stomach and small intestine contractions. Its activity is important for the interdigestive migrating motor complex which moves undigested food through the gastrointestinal tract during fasting periods.

Pathways

Motilin receptor activation significantly impacts the motility and secretory pathways involved in gastrointestinal regulation. It interacts with other proteins in the gastrointestinal signaling network including ghrelin and gastrin to efficiently coordinate motility. The motilin receptor modulates cyclic AMP levels and calcium signaling pathways essential for smooth muscle contractions thereby assisting in coordinated gastrointestinal movements.

The motilin receptor is closely linked to gastrointestinal functional disorders such as gastroparesis and irritable bowel syndrome (IBS). Alterations in receptor activity can lead to disrupted motility and contribute to these conditions. The receptor also associates with ghrelin in the context of functional gastrointestinal disorders as both influence motility patterns. Understanding motilin receptor mechanisms can therefore inform therapeutic strategies for managing these digestive ailments.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for motilin.
See full target information MLNR
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of medical sciences 22:3556-3564 PubMed40959576

2025

Vascular Endothelial Protection Effects of Root Aqueous Extracts on LPS-induced Rat Vascular Damage.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Hsien Chen,Sheau-Chung Tang,Shu-Er Yang,Erl-Shyh Kao
View all publications
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