Rabbit Polyclonal Motilin receptor antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human MLNR.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human MLNR. The exact immunogen used to generate this antibody is proprietary information. Database link O43193
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Gorilla | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Gorilla | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Alternative names
GPR38, MTLR, MTLR1, MLNR, Motilin receptor, G-protein coupled receptor 38
Recommended products
Rabbit Polyclonal Motilin receptor antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human MLNR.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human MLNR. The exact immunogen used to generate this antibody is proprietary information. Database link O43193
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The motilin receptor also known as GPR38 is a G-protein-coupled receptor (GPCR) with a molecular mass of approximately 45 kDa. This receptor primarily binds to motilin a peptide hormone. It is expressed in the smooth muscle cells of the gastrointestinal tract notably in areas like the stomach and small intestine. By coupling with G-proteins the motilin receptor initiates intracellular signaling cascades that result in physiological responses.
- Biological function summary
The motilin receptor plays an important role in regulating gastrointestinal motility. This receptor upon binding motilin triggers contractions in the smooth muscles of the digestive tract. It does not form part of a larger receptor complex and functions independently to modulate stomach and small intestine contractions. Its activity is important for the interdigestive migrating motor complex which moves undigested food through the gastrointestinal tract during fasting periods.
- Pathways
Motilin receptor activation significantly impacts the motility and secretory pathways involved in gastrointestinal regulation. It interacts with other proteins in the gastrointestinal signaling network including ghrelin and gastrin to efficiently coordinate motility. The motilin receptor modulates cyclic AMP levels and calcium signaling pathways essential for smooth muscle contractions thereby assisting in coordinated gastrointestinal movements.
- Associated diseases and disorders
The motilin receptor is closely linked to gastrointestinal functional disorders such as gastroparesis and irritable bowel syndrome (IBS). Alterations in receptor activity can lead to disrupted motility and contribute to these conditions. The receptor also associates with ghrelin in the context of functional gastrointestinal disorders as both influence motility patterns. Understanding motilin receptor mechanisms can therefore inform therapeutic strategies for managing these digestive ailments.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Motilin receptor antibody - C-terminal (ab188926)
Immunohistochemistry analysis of formalin/PFA-fixed paraffin-embedded Human uterus, vessel labeling Motilin receptor tissue with ab188926 at 10μg/ml.
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