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Mouse IgG1, kappa monoclonal [MOPC-21] - isotype control Cited in 55 publications.

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Images

Immunoprecipitation - Mouse IgG1, kappa monoclonal [MOPC-21] - isotype control (AB18443), expandable thumbnail
  • Immunoprecipitation - Mouse IgG1, kappa monoclonal [MOPC-21] - isotype control (AB18443), expandable thumbnail
  • Immunoprecipitation - Mouse IgG1, kappa monoclonal [MOPC-21] - isotype control (AB18443), expandable thumbnail
  • Immunoprecipitation - Mouse IgG1, kappa monoclonal [MOPC-21] - isotype control (AB18443), expandable thumbnail
  • Immunoprecipitation - Mouse IgG1, kappa monoclonal [MOPC-21] - isotype control (AB18443), expandable thumbnail

Publications

  • RNA biology 21:1-92023
    Multiple Oligo assisted RNA Pulldown via Hybridization followed by Mass Spectrometry (MORPH-MS) for exploring the RNA-Protein interactions.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    Priyanka Pant,Regalla Kumarswamy
    PubMed 38105541
  • Nature metabolism 5:1911-19302023
    Vitamin B is a limiting factor for induced cellular plasticity and tissue repair.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    Marta Kovatcheva,Elena Melendez,Dafni Chondronasiou,Federico Pietrocola,Raquel Bernad,Adrià Caballe,Alexandra Junza,Jordi Capellades,Adrián Holguín-Horcajo,Neus Prats,Sylvere Durand,Meritxell Rovira,Oscar Yanes,Camille Stephan-Otto Attolini,Guido Kroemer,Manuel Serrano
    PubMed 37973897

Key facts

Isotype

IgG1

Host species

Mouse

Storage buffer

pH: 7.2
Preservative: 0.09% Sodium azide
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Reactivity data

Application

IP

Reactivity

Expected

Dilution info

-

Notes

-

Application

IHC-Fr

Reactivity

Expected

Dilution info

-

Notes

-

Application

WB

Reactivity

Expected

Dilution info

-

Notes

-

Application

IHC-P

Reactivity

Expected

Dilution info

-

Notes

-

Application

Flow Cyt

Reactivity

Expected

Dilution info

-

Notes

Suitable for surface or intracellular staining.

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      Target data

      Function

      Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

      Alternative names

      Immunoglobulin heavy constant gamma 4, Ig gamma-4 chain C region, IGHG4

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      Mouse IgG1, kappa monoclonal [MOPC-21] - isotype control Cited in 55 publications.

      Alternative names

      Immunoglobulin heavy constant gamma 4, Ig gamma-4 chain C region, IGHG4

      Key facts

      Isotype

      IgG1

      Form

      Liquid

      Clonality

      Monoclonal

      Clone number

      MOPC-21

      Purification technique

      Affinity purification Protein G

      Specificity

      MOPC-21 immunoglobulin has unknown specificity and was chosen as an isotype control after screening on a variety of resting, activated, live and fixed rat and human tissues.

      Light chain type

      kappa

      Concentration
      Loading...

      Storage

      Shipped at conditions

      Blue Ice

      Appropriate long-term storage conditions

      +4°C

      Notes

      ab18443 MOPC-21 immunoglobulin is useful as an isotype-matched control in Western blotting, immunoprecipitation, immunohistochemical staining, bioassay and immunofluorescent staining (surface or intracellular) for flow cytometric analysis.

      Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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