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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Recombinant Monoclonal IGHM antibody. Suitable for ICC, IP, Flow Cyt, ELISA, IHC-P and reacts with Mouse, Recombinant fragment, Recombinant full length protein - Mouse samples. Cited in 3 publications. Immunogen corresponding to Full Length Protein corresponding to Mouse Immunoglobulin heavy constant mu.
IgG
Rabbit
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 48% PBS, 1% BSA
Liquid
Monoclonal
ICC | IP | Flow Cyt | ELISA | IHC-P | |
---|---|---|---|---|---|
Mouse | Expected | Expected | Expected | Predicted | Expected |
Recombinant fragment | Not recommended | Expected | Not recommended | Not recommended | Not recommended |
Recombinant full length protein - Mouse | Not recommended | Not recommended | Not recommended | Tested | Not recommended |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Recombinant fragment, Recombinant full length protein - Mouse | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Recombinant fragment, Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Recombinant full length protein - Mouse | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info - | Notes ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody. |
Species | Dilution info | Notes |
---|---|---|
Species Recombinant fragment, Recombinant full length protein - Mouse | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Recombinant full length protein - Mouse | Dilution info 0.005-0.2 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Recombinant fragment | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Recombinant fragment, Recombinant full length protein - Mouse | Dilution info - | Notes - |
IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions (By similarity).
Immunoglobulin heavy constant mu, Igh-6, Ighm
Rabbit Recombinant Monoclonal IGHM antibody. Suitable for ICC, IP, Flow Cyt, ELISA, IHC-P and reacts with Mouse, Recombinant fragment, Recombinant full length protein - Mouse samples. Cited in 3 publications. Immunogen corresponding to Full Length Protein corresponding to Mouse Immunoglobulin heavy constant mu.
Immunoglobulin heavy constant mu, Igh-6, Ighm
IgG
Rabbit
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 48% PBS, 1% BSA
Liquid
Monoclonal
RM109
Affinity purification Protein A
This antibody reacts to mouse IgM. No cross reactivity with mouse IgG1, IgG2a, IgG2b, IgG3, IgA, IgE, human IgG, rat IgG, or goat IgG. The Fc region of RM109 has been engineered to eliminate the binding of Fc receptor.
ab190369 was purified from an animal origin–free and protein-free culture supernatant.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Mouse IgM acts as a pivotal component in the body's defense mechanisms against infections. It forms part of a complex known as the complement system particularly activating the classic complement pathway. This activation facilitates opsonization where pathogens are marked for ingestion and destruction by macrophages and other immune cells. Alongside IgG antibodies Mouse IgM plays a vital role in immune surveillance and rapid response to foreign antigens although IgM is larger and less specialized compared to its IgG counterpart.
Mouse IgM also known as Immunoglobulin M is an essential type of antibody found in mice with a molecular mass of approximately 970 kDa. This antibody is mainly expressed in the blood and lymphatic fluid and is the first antibody produced by B cells upon exposure to an antigen. The pentameric form of Mouse IgM has ten antigen-binding sites which enhances its ability to neutralize pathogens effectively and forms the foundation of the initial immune response.
Mouse IgM is critically connected to the classical complement activation pathway and the B cell signaling pathway. In the complement cascade it interacts with C1 complex beginning the process of pathogen elimination. In the context of B cell receptor-mediated signaling IgM antibodies serve as receptors on naive B cells synergizing with proteins such as Ig-alpha and Ig-beta to initiate signaling cascades essential for B cell maturation and differentiation. These pathways ensure the development of a robust adaptive immune response.
Dysfunction or deficiency in Mouse IgM can lead to conditions such as immunodeficiencies and autoimmune disorders. For instance a lack of functional IgM results in hyper-IgM syndrome where there is an elevated level of IgG but low levels of IgM impacting the body's ability to fight infections. Additionally systemic lupus erythematosus an autoimmune disease is often associated with abnormal IgM activity. During this condition improper interaction with IgG may exacerbate autoantibody production highlighting the complex relationship between IgM and other immunoglobulins in managing immune health.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
A titer ELISA of mouse IgM. The plate was coated with different amounts of mouse IgM. A serial dilution of ab190369 was used as the primary antibody. An alkaline phosphatase conjugated anti-rabbit IgG as the secondary antibody.
ELISA of mouse immunoglobulins shows ab190369 reacted to mouse IgM; no cross reactivity with IgG1, IgG2a, IgG2b, IgG3, IgA, IgE, human IgG, rat IgG, or goat IgG. The plate was coated with 50 ng/well of different immunoglobulins. 200 ng/mL, 50 ng/mL, or 10 ng/mL of ab190369 was used as the primary antibody. An alkaline phosphatase conjugated anti-rabbit IgG as the secondary antibody.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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