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AB174603

Anti-Mouse MHC Class I H 2Dd antibody [34-1-2S] - Low endotoxin, Azide free

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(1 Publication)

Mouse Monoclonal HA13 antibody. Carrier free. Suitable for Flow Cyt, FuncS and reacts with Mouse samples. Cited in 1 publication.

View Alternative Names

H-2D(K), H2-D1

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

34-1-2S

Isotype

IgG2a

Light chain type

kappa

Carrier free

Yes

Reacts with

Mouse

Applications

FuncS, Flow Cyt

applications

Specificity

ab174603 reacts with the mouse MHC class I, H-2Kd and H-2Dd. This cytotoxic antibody also cross-reacts with Kb, s, r, q, p.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "FuncS" : {"fullname" : "Functional Studies", "shortname":"FuncS"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>In a final volume of 100 uL. <a href='/en-us/products/primary-antibodies/mouse-igg2c-kappa-monoclonal-18c8bc7ad10-isotype-control-ab170191'>ab170191</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>", "FuncS-species-checked": "guaranteed", "FuncS-species-dilution-info": "", "FuncS-species-notes": "<p></p>" } } }
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Product details

Endotoxin: Less than 0.001 ng/ug antibody, as determined by the LAL assay.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.2
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Mouse MHC Class I H-2Dd also known as H-2Dd or simply 2Dd is a major histocompatibility complex (MHC) protein. It has a critical role in the immune system by presenting peptide antigens to CD8+ T cells. The protein has a mass of approximately 45 kilodaltons. H-2Dd is mainly expressed on the surface of nearly all nucleated cells in mice serving as an important component in immune recognition.
Biological function summary

The H-2Dd protein forms a complex with beta-2 microglobulin to create the MHC class I molecule. This complex plays an essential role in the identification and elimination of infected or transformed cells by the immune system. Specifically it binds to small peptide fragments derived from cytosolic proteins and displays them on the cell surface for surveillance by cytotoxic T lymphocytes.

Pathways

H-2Dd is involved in antigen processing and presentation pathways. It operates within the context of the adaptive immune response a pathway where it interacts with transporter associated with antigen processing (TAP). Another important pathway is the proteasome degradation pathway that generates peptide fragments presented by H-2Dd. The closely related MHC class I molecules like H-2Kk also participate in these processes ensuring proper immune system function.

H-2Dd's role ties prominently to autoimmune diseases and transplant rejection. Variations in this protein can influence susceptibility to autoimmune conditions such as rheumatoid arthritis by altering the peptide presentation to T cells. H-2Dd is also connected to graft-versus-host disease during transplantation procedures where its mismatch can trigger immune rejection. In such cases interactions with other proteins like H-2Dd related peptides exacerbate the immune response necessitating careful consideration in clinical settings.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the presentation of foreign antigens to the immune system.
See full target information H2-D1

Additional targets

H2-D1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology (Baltimore, Md. : 1950) 142:2736-42 PubMed2467936

1989

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

Applications

Unspecified application

Species

Unspecified reactive species

R T Kubo,W Born,J W Kappler,P Marrack,M Pigeon
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Product promise

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