Anti-MOX1/MEOX1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

MOX1 also known as MEOX1 or mesenchyme homeobox 1 is a homeobox protein. The molecular weight of MEOX1 is approximately 34 kDa. This protein functions as a transcription factor meaning it binds to specific DNA sequences to regulate gene expression. MEOX1 expresses mainly in the mesoderm during embryonic development and in various adult tissues including muscles and skin. Its activity is critical for tissue formation particularly in the developing mesodermal tissues.

Biological function summary

MEOX1 plays a role in segment identity and myogenesis. It helps direct the formation of somites which are essential precursor structures for the vertebral column and skeletal muscles. MEOX1 does not function alone; it often interacts with other homeobox proteins forming complexes that finely control the transcription of genes essential for development. This interaction ensures proper segment patterning and muscle differentiation important for normal embryonic development.

Pathways

MEOX1 has an essential place in the Wnt signaling and Notch signaling pathways. These pathways are significant during embryogenesis for the regulation of development and cell fate decisions. In these pathways MEOX1 interacts with proteins like TCF/LEF family members and the Notch intracellular domain. The integration of MEOX1 into these pathways underpins its ability to influence various developmental processes indicating its extensive regulatory potential.

Associated diseases and disorders

MEOX1 mutations link to Klippel-Feil syndrome a disorder characterized by the abnormal fusion of spinal vertebrae. This connection highlights the protein's role in vertebral segmentation. Additionally abnormal MEOX1 activity may contribute to muscle development disorders implicating its involvement in myogenic pathways. While not directly connected proteins like PAX1 and PAX3 also relate to these conditions sharing roles in skeletal and muscle development supporting coordinated gene networks that maintain normal anatomical structures.