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AB105349

Anti-MOX1/MEOX1 antibody

1

(1 Review)

|

(4 Publications)

Rabbit Polyclonal MOX1/MEOX1 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MEOX1.

View Alternative Names

MOX1, MEOX1, Homeobox protein MOX-1, Mesenchyme homeobox 1

3 Images
Western blot - Anti-MOX1/MEOX1 antibody (AB105349)
  • WB

Supplier Data

Western blot - Anti-MOX1/MEOX1 antibody (AB105349)

1 h incubation at RT in 8% NFDM/TBST.

Lane 1:

Western blot - Anti-MOX1/MEOX1 antibody (ab105349) at 1 µg/mL

Lane 1:

Western blot - Anti-MOX1/MEOX1 antibody (ab105349) at 2 µg/mL

All lanes:

Human tonsil tissue lysate at 15 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG HRP conjugate at 1/10000 dilution

false

Western blot - Anti-MOX1/MEOX1 antibody (AB105349)
  • WB

Supplier Data

Western blot - Anti-MOX1/MEOX1 antibody (AB105349)

1h incubation at RT in 8% NFDM/TBST.

All lanes:

Western blot - Anti-MOX1/MEOX1 antibody (ab105349) at 2 µg/mL

Lane 1:

Rat heart tissue lysate at 15 µg

Lane 2:

Rat testis tissue lysate at 15 µg

Lane 3:

Rat colon tissue lysate at 15 µg

Lane 4:

Rat skeletal muscle tissue lysate at 15 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG HRP conjugate at 1/10000 dilution

false

Western blot - Anti-MOX1/MEOX1 antibody (AB105349)
  • WB

Supplier Data

Western blot - Anti-MOX1/MEOX1 antibody (AB105349)

1 h incubation at RT in 8% NFDM/TBST.

All lanes:

Western blot - Anti-MOX1/MEOX1 antibody (ab105349) at 2 µg/mL

Lane 1:

Mouse colon tissue lysate at 15 µg

Lane 2:

Mouse skeletal muscle tissue lysate at 15 µg

Lane 3:

Mouse thymus tissue lysate at 15 µg

Lane 4:

Mouse pancreas tissue lysate at 15 µg

Lane 5:

Mouse stomach tissue lysate at 15 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG HRP conjugate at 1/10000 dilution

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse, Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human MEOX1. The exact immunogen used to generate this antibody is proprietary information.

P50221

Specificity

Predicted to not crossreact with MOX2.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MOX1 also known as MEOX1 or mesenchyme homeobox 1 is a homeobox protein. The molecular weight of MEOX1 is approximately 34 kDa. This protein functions as a transcription factor meaning it binds to specific DNA sequences to regulate gene expression. MEOX1 expresses mainly in the mesoderm during embryonic development and in various adult tissues including muscles and skin. Its activity is critical for tissue formation particularly in the developing mesodermal tissues.
Biological function summary

MEOX1 plays a role in segment identity and myogenesis. It helps direct the formation of somites which are essential precursor structures for the vertebral column and skeletal muscles. MEOX1 does not function alone; it often interacts with other homeobox proteins forming complexes that finely control the transcription of genes essential for development. This interaction ensures proper segment patterning and muscle differentiation important for normal embryonic development.

Pathways

MEOX1 has an essential place in the Wnt signaling and Notch signaling pathways. These pathways are significant during embryogenesis for the regulation of development and cell fate decisions. In these pathways MEOX1 interacts with proteins like TCF/LEF family members and the Notch intracellular domain. The integration of MEOX1 into these pathways underpins its ability to influence various developmental processes indicating its extensive regulatory potential.

MEOX1 mutations link to Klippel-Feil syndrome a disorder characterized by the abnormal fusion of spinal vertebrae. This connection highlights the protein's role in vertebral segmentation. Additionally abnormal MEOX1 activity may contribute to muscle development disorders implicating its involvement in myogenic pathways. While not directly connected proteins like PAX1 and PAX3 also relate to these conditions sharing roles in skeletal and muscle development supporting coordinated gene networks that maintain normal anatomical structures.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed : 23290072, PubMed : 24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis : specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
See full target information MEOX1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:5183 PubMed38431730

2024

Analysis of immunoinfiltration and EndoMT based on TGF-β signaling pathway-related genes in acute myocardial infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Shen,Junqing Liang,Manzeremu Rejiepu,Zhiqin Ma,Jixian Zhao,Jia Li,Ling Zhang,Ping Yuan,Jianing Wang,Baopeng Tang

Frontiers in pharmacology 11:528267 PubMed33132907

2020

PPARα Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis Regulating MEOX1.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wang,Qin Fang,Zhihao Zhang,Daowen Wang,Lujin Wu,Yan Wang

The Journal of biological chemistry 293:8712-8719 PubMed29678882

2018

Mesenchyme homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors.

Applications

Unspecified application

Species

Unspecified reactive species

Kun Dong,Xia Guo,Weiping Chen,Amanda C Hsu,Qiang Shao,Jian-Fu Chen,Shi-You Chen

Data in brief 16:266-270 PubMed29204471

2017

Data on the involvement of Meox1 in balloon-injury-induced neointima formation of rats.

Applications

Unspecified application

Species

Unspecified reactive species

Bing Wu,Lei Zhang,Yun-He Zhu,You-En Zhang,Fei Zheng,Jian-Ye Yang,Ling-Yun Guo,Xing-Yuan Li,Lu Wang,Jun-Ming Tang,Shi-You Chen,Jia-Ning Wang
View all publications
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